CLL 101
This laboratory technique is used to confirm the CLL diagnosis by identifying characteristic B-cell markers such as CD5 and CD19?
What is flow cytometry?
Patients with mutated IGHV, favorable genetics, and no symptoms are often managed with this approach instead of immediate treatment.
What is watchful waiting (active surveillance)?
The PI recommends advising patient to use this preventative measure because of the risk of skin cancers.
What is sun protection?
This Phase 3 trial compared pirtobrutinib monotherapy vs. BR in previously untreated CLL/SLL patients.
What is BRUIN 313?
This one-word sign hangs above the AFC Richmond locker room door.
What is BELIEVE?
These 2 staging systems are most commonly used to assess the extent of CLL.
What are the Rai and Binet staging systems?
Patients with TP53 mutation are generally treated with these targeted agents rather than older chemoimmunotherapy.
What are BTK & BCL2 inhibitors?
An 82 year old patient taking 8 chronic medications starts Brukinsa. The clinician should pay special attention to interactions involving this particular enzyme system.
What is CYP3A?
Despite an effective crossover rate exceeding 50%, this key secondary endpoint in BRUIN 313 still favored pirtobrutinib?
What is OS?
Ted often says people should be this instead of judgmental?
What is curious?
A deletion on chromosome 17 involving this tumor suppressor gene predicts a higher-risk for of CLL.
What is TP53?
What is Tumor Lysis Syndrome? Impaired renal function, high tumor burden, splenomegaly.
The Brukinsa PI states this number of contraindications.
What is none?
BRUIN 314 directly compared pirto against this covalent BTK inhibitor?
What is ibrutinib?
Dani Rojas famously says soccer is this.
What is life?
Enlarged lymph nodes, night sweats, weight loss, and fatigue are examples of these symptoms that may indicate the need for treatment.
What are B symptoms?
High out of pocket costs, copays, and deductibles are examples of this increasingly recognized burden experienced by cancer patients.
What is financial toxicity?
The PI recommends monitoring this laboratory parameter throughout treatment due to the risk of DILI?
What are hepatic function tests?
Pirto was developed to inhibit both wild type BTK and this important resistance-associated mutation.
What is BTK C481 mutation?
Instead of creating a team built around individual stars, Ted emphasizes this quality.
What is teamwork?
This prognostic scoring system combines age, clinical stage, Beta2 microglobulin, IGHV mutation status, and TP53 status to stratify patients into risk groups.
What is CLL-IPI? International Prognostic Index
Venetoclax based regimens with obinutuzumab require these premedications.
What is hydration, allopurinol, IV dexamethasone or methylprednisolone, acetaminophen, antihistamine.
The PI recommends consideration of prophylaxis against this opportunistic fungus in appropriate patients.
What is pneumocytis jirovecii (PJP)?
Patients with this cytogenetic abnormality were excluded from BRUIN 313.
What is del 17p?
These are Ted's trademark homemade snacks for Rebecca.
What are biscuits?