Amino acids
The smallest amino acid
What is glycine?
The call sign for Tom Cruise
What is Maverick?
The ER channel for importing proteins as they are synthesized
What is Sec61? (also acceptable "translocon")
The sequence that gets proteins out of the nucleus
What is a nuclear exit signal?
The coating protein that mediates ER-->Gogli vesicle traffic
COPII
The amino acid to which sugars are attached to inside the ER
What is asparagine?
The name of the aircraft that is flown in top gun
what is an F-14?
The protein that stalls translation when signal sequences emerge from the ribosome
What is signal recognition particle?
Met-Met-Ser-Phe-Val-Ser-Leu-Leu--Leu-Val-Gly-Ile-Leu-Phe-Trp-Ala-Thr-Glu-Ala-Glu-Gln-leu-Thr-Lys-Cys-Glu-Val-Phe-Gln
What is an ER signal sequence?
when proteins misfold in the ER and are sent back to the cytosol for degradation
An amino acid with a benzene (6 membered) ring that is hydrophobic
What is phenylalanine?
Maverick's wingman?
Iceman
The enzyme responsible for cleaving N-terminal ER signal sequences
What is signal peptidase?
Pro-Pro-Lys-Lys-Lys-Arg-Lys_Val
What is a nuclear important sequence?
the protein that deforms the membrane inward and is largely associated with endocytosis (and Golgi transport)
The largest of the three amino acids that can be phosphorylated
What is tyrosine?
Maverick's co-pilot
Who is Goose?
The protein that gets the stalled ribosome to Sec61
What is the SRP receptor?
Met-Glu-Glu-Leu-Ser-Gln-Ala-Leu-Ala-Ser-Ser-Phe
What is a nuclear export sequence?
this GPI-anchored cell surface protein appears to cause trouble when it is either in a transmembrane topology or cytosolic localization
prion protein (PrP)
the amino acid that doesn't pack nicely into a helical conformation
What is proline?
Max speed achieved in Top Gun Maverick test flight
What is Mach 10?
What is protein disulfide isomerase?
The sequence that leads to ER retention/retrieval
What is a "KDEL"?
This enzyme pinches off the "necks" of assembled vesicles and is required for vesicular transport
Dynamin