Cytoskeleton
The microtubule subunit that can bind GTP but not hydrolyze it.
What is alpha tubulin?
The four stages of mitosis (in order).
What are prophase, metaphase, anaphase, and telophase?
The protein that binds to and inhibits E2F.
What is Rb? (Retinoblastoma Protein)
A proto-oncogene transcription factor that leads to the transcription of G1 Cyclin/CDK.
What is Myc?
Mutations in this kinase often cause cells to grow bigger and bigger without dividing.
What is CAK?
A phenomenon that occurs when the length of a filament stays relatively constant, even though subunits are constantly being added and removed.
What is treadmilling? (poleward flux also accepted)
The kinase that adds an inhibitory phosphate to M CDK.
What is Wee1?
A G-protein and proto-oncogene.
What is ras?
If this protein were mutated so that it could not be phosphorylated, DNA replication could occur multiple times per cycle.
What is Cdc6?
If a sheet of cells without this type of filament are stretched, they typically rupture/break apart.
What are intermediate filaments?
Progression into this mitosis stage is inhibited if Mad2 is active.
What is anaphase?
Proteins that mediate the cleavage cascade that ends in death of the cell.
What are caspases?
This type of gene in a wild-type cell acts to slow down/inhibit the cell cycle.
What is a tumor suppresor gene?
A mutation in this actin binding protein could cause myosin to be blocked from binding to actin, so muscle contraction could not occur.
What is troponin? (tropomyosin is also acceptable)
The filament and junction type involved in cell crawling.
What are actin filaments and focal adhesions?
Protein that assists in converting a side-capture to an end-capture.
What is CENP-E?
The specificity factor for APC that allows it to target M Cyclin for degradation.
What is Cdh1?
Tumor repressor genes require this many mutation events to be considered harmful/cancer-causing.
What is two?
A mutation in this motor protein could result in the inability of proteins synthesized in the neuron cell body to be transported to the axon terminals.
What is kinesin?
Step/action of myosin "walking" that causes power stroke.
What is the release of Pi?
If the nucleus of a cell is compared to locations on a clock, if the centrosome is at 12 o'clock, the point of greatest tension (and thus rupture) due to dynein is at this location on the clock.
What is 6 o'clock?
Target(s) of SCF.
What are P27 and Cdc6?
Protein that, when mutated, increases the likelihood of acquiring other cancerous mutations.
What is p53?
A loss-of-function mutation in these complexes could affect heart cells' ability to beat synchronously.
What are gap junctions? (connexon/connexins also accepted)