Signalling Pathway
This protein is found inside the cell membrane and is activated when bound to GTP.
What is Ras?
These proteins are able to phosphorylate something after being activated by a cyclin.
What are cyclin-dependent-kinases?
This protein is the "master regulator" of cell cycle arrest pathways.
What is p53?
A mutation in either of these types of genes could result in uncontrolled cell proliferation?
What are proto-oncogenes (or oncogenes) and tumor-suppressor genes?
This transcription factor turns on the production of cyclins.
What is c-MYC?
To move from G1 to S phase, this protein must be phosphorylated.
What is Rb?
Mdm2 is a good example of this sort of cancer-causing gene, because it facilitates the degradation of p53.
What is a proto-oncogene/oncogene?
What is DNA repair?
A mutation in the gene that codes for Ras could cause uncontrolled cell proliferation. That's because Ras is this kind of gene.
What is a proto-oncogene?
This transcription factor turns on genes for DNA replication machinery.
What is EF?
To block the G1 to S transition, p53 upregulates the transcription of this gene.
What is p21?
Although cancer is not typically thought of as an infectious disease, it can sometimes be caused by these.
What are viruses?
Hyperactive c-MYC could be the result of this many mutant alleles.
What is one?
After cyclin B binds its CDK, this must happen before the mitosis promoting factor is active.
What is de-phosphorylation?
A mutation in this gene could mean that the mitosis promoting factor is dephosphorylated, even when the cell is not ready for mitosis.
What is 14-3-3 sigma?
He proposed the two-hit model.
Who is Knudson?
These are the sort of mutations that can cause RAS to be overactive and result in uncontrolled cell proliferation.
What is dominant?
What are tumor suppressor genes?
GADD-45 is involved in slowing down this phase of the cell cycle.
What is S phase?
She said: "All cancers are genetic, but not all cancers are inherited"
Who is Mary Claire King?