Microorganisms
Involved
Involved
What Microorganism is Primarily responsible for creating these Biofilms?
Staphylococcus aureus- also known as STAPH.
Prosthetic Joint Infections have a similar mortality rate to what other illnesses.
Cancers such as prostate or breast cancer.
Does bacteria like to develop on Biotic or Abiotic surfaces? Why?
Bacteria prefer to develop on abiotic surfaces such as the materials used for prosthetics, which is what makes prosthetic joint procedures at high risk for biofilms and antibiotic resistance. -They prefer these abiotic surfaces because there are no live cells interfering with their reproduction.
Biofilms affect ___ to ___ percent of prosthetic joint procedures.
65% to 80% of cases.
Do patients with PJI’s suffer from acute or chronic joint pain?
Chronic. Although a person can have either chronic or acute pain, majority of PJI cases have to get many follow up treatments/surgeries. This is because there are no easy ways to remove every trace of the infection in one go(due to the biofilms.) If not treated ASAP, the chances of only having acute symptoms significantly decline.
Both Staphylococcus Aureus and S. Epidermis are responsible for the formation of Biofilms in roughly _____ % of Prosthetic Joint Infections(PJI.)
75 Percent.
PJI’s have a ___ to ___ percent mortality rate in 5 years.
What is the thick coating that forms around the bacteria and what is it’s purpose?
This thick slimy coating is called the ”Matrix”. The main purpose of this structure is to defend the biofilm/bacteria from antibiotics trying to get through.
Do biofilms increase or decrease PJI morbidity?
Biofilms INCREASE morbidity in PJI cases. The shield that these biofilms create can be close to a thousand times stronger at fending off antibiotics.
True or False: Common illness symptoms such as low grade fevers and fatigue can also be caused from PJI’s.
True.
Which Microorganism is commonly overlooked due to its slow growth?
* Hint: Often forms after a shoulder Arthroplasty.
Cutibacterium Acnes.
True or False: Things such as gender and age can be a factor in having a higher mortality rate from PJI’s.
True. Being male or of older age has been linked back to higher mortality rates than others.
The biofilm allows bacteria to become dormant(asleep,) on the inside where they are protected. How does this benefit the bacteria?
Since antibiotics focus on fighting off active(awake) bacteria, the drugs look past the dormant bacteria. This allows them to stay inside the host until the medication has worn off, which then allows them to start attacking again later.
True or False: Not only does the PJI affect the joints and implant, but it can also weaken the whole immune system leading to bigger fatal conditions such as sepsis.
TRUE.
Do patients with PJI‘s suffer from-
* Joint stiffness, Joint swelling, Joint redness, drainage, and sometimes even a damaged prosthesis?
Yes. These are all symptoms that indicate a patient has a prosthetic joint infection.