Bleeding
The factor that reflects adult levels at birth - factor 8 or 9.
What is factor 8?
Name 4 risk factors for thrombosis
Central venous access device
Inherited thrombophilia
Anatomic abnormalities
Antiphospholipid antibody syndrome
Cancer
Inflammatory bowel disease
Nephrotic syndrome
Trauma or major surgical procedures
Pregnancy or estrogen therapy
Iron-deficiency anemia
Obesity
Immobility
Sickle cell disease
Dehydration
Most common cause of thrombocytopenia in children
What is viral infection?
Two natural anticoagulants
What are protein C and S?
Subcutaneous blood thinner commonly used to treat thrombosis
What is Lovenox/ Enoxaparin (LMWH)?
Factor deficiency (even severe) that does NOT prolong PT or PTT.
What is factor 13 deficiency?
Factor V Leiden is characterized by factor V resistance to inactivation by _____.
What are protein C and S?
A platelet parameter on CBC that supports diagnosis of acute ITP
What is increased MPV?
Vitamin K deficiency first prolongs ____ time
What is PT?
Thrombophilia disorders in which warfarin should be used with caution
What is Protein C or S deficiency?
This is the most common type of bleeding in hemophilia
What is hemarthrosis (joint bleeding)?
A 2 y.o. girl who drinks 50oz of milk daily presents with hemoglobin 2.1, MCV 55, altered mental status, and papilledema. What is the most likely complication she has developed?
Name two treatment options for acute ITP
Observation, steroids, IVIG, Anti-Rh immunoglobulin (RhoGAM), splenectomy
Screening tests for antiphospholipid syndrome
Lupus Inhibitor, Cardiolipin IgG/IgM, Beta-2-glycoprotein IgG/IgM
Medication that can treat both mild Hemophilia A and von Willebrand disease (type 1)
What is Desmopressin/ DDAVP (Stimate)?
This is the inherited coagulation disorder with 8 subtypes
What is von Willebrand disease?
False
Classic triad in Wiskott-Aldrich syndrome
What is thrombocytopenia (small), eczema, and recurrent infections?
Tissue factor primarily activates factor ____ in the ____ pathway.
Factor 7; Extrinsic pathway
Supportive medication(s) useful for nosebleeds and heavy menses
What are Antifibrinolytics (Amicar, TXA)?
Most severe form of VWD
What is Type 3?
May-Thurner syndrome occurs in which leg?
What is the left leg? (Right common iliac artery compresses left common iliac vein).
1:1 mixing study that does not correct with addition of normal plasma suggests what?
Presence of coagulation inhibitor
Eltrombopag and romiplostim bind to this receptor on megakaryocytes
What is thrombopoietin?