Hemoglobin and Oxygen Transport
The number of globins in a hemoglobin
What is 4?
A protein inside cells that stores iron
What is ferritin?
The term for a low platelet count
What is thrombocytopenia?
RBCS make ATP using anaerobic glycolysis because they lack this cell organelle
What are mitochondria?
T lineage cells mature in this organ
What is the thymus?
The most common type of hemoglobin found in adults
What is HbA?
Cells display these receptors when they need more iron
What are TfR1 receptors?
All blood cells are derived from this type of stem cell
What are hematopoietic stem cells?
IV Iron is combined with this compound in order to prevent toxicity
What is sugar (carbohydrates)?
The type of stain used to visualize hematopoietic cells in smears
What is a Wright stain?
Oxygen binds to hemoglobin when it is in this state
What is a "relaxed" state?
The oxidation state of iron that allows for better storage
What is Fe3+?
Since 1998, grain products in North America have been fortified with this compound to help prevent a type of anemia
What is folate (folic acid)?
DAILY DOUBLE #2
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What is G6PD (glucose-6-phosphate-dehydrogenase)?
This factor may stimulate the self-renewal of hematopoietic stem cells (HSCs)
What is stem cell factor (SCF)?
A majority of carbon dioxide in the blood is transported as this ion
What are bicarbonate?
Tissues with high oxygen demand will have a monomer of hemoglobin called this
What is myoglobin?
DAILY DOUBLE #1
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What is hookworm infection?
Folate deficiency leads to deficient synthesis of this compound, leading to deficient DNA replication
What is dTTP (Deoxythymidine triphosphate)?
The precursor cell that form platelets through budding of the cytoplasm
What are megakaryocytes?
Short term: Temperature, pH, CO2
Long-term: 2,3-BPG
The inheritance pattern for hereditary HFE hemochromatosis
What is autosomal recessive?
A group of symptoms that is unique to B12 (Cobalamin) deficiency
What are neuropsychiatric symptoms?
Plasma or serum levels of this enzyme provide a good measure of necrotic cell death
What is Lactate Dehydrogense (LDH)?
This cytokine controls the maturation of monoblasts
What is M-CSF (Monocyte Colony-Stimulating Factor)?