Drugs and the Immune System
The field that studies the interplay between drugs and the immune system
What is immunopharmacology?
What is hemopexin?
The mnemonic for the four types of hypersensitivity
What is ACID?
1. Acute/Anaphylactic
2. Cytotoxic
3. Immune-Complex
4. Delayed hypersensitivity
If this antibody is bound to RBCs, it can cause intravascular hemolysis
What is IgM?
This protozoa is the most common in causing malaria
Plasmodium falciparum
This class of drugs is employed in most combination immunosuppressant regimens
These cells breaks down hemoglobin in the spleen
What are macrophages?
The hypothesis that explains the increasing frequency of allergies in developed countries
Once a blood product has been spiked, the whole blood bag must be transfused within this amount of time
What is 4 hours?
DAILY DOUBLE! #2
Place your bet.
1. G6PD deficiency trait
2. Sickle hell hemoglobin (heterozygote)
3. Absence of Duffy blood group determinants
DAILY DOUBLE! #1
Place your bet
Basiliximab and Daclizumab
Gilbert syndrome is due to a hereditary, moderate deficiency of this enzyme.
What is bilirubin UDP-glucuronosyl transferase
The only antibody type that binds to mast cells
What is IgE?
This test looks for antibodies or complement bound to the patient's red blood cells in vivo
What is a direct Coomb's test?
Malaria relapse occurs due to the presence of these dormant forms in the malarial life cycle that "hide" in the liver
What are hypnozoites?
This enzyme is part of the metabolic mechanism for clearing azathioprine
What is xanthine oxidase?
This disease, commonly found among the Amish, is due to a very rare, inherited, near-complete deficiency of UDP-glucuronosyl.
The cytokine responsible for B-cell class switching to IgE
What is IL-4?
Cryoprecipitate provides a high dose of this glycoprotein in a small volume
What is fibrinogen?
This cytokine has been correlated with cerebral malaria
What is TNF-alpha?
This drug is used to treat an Rh-negative mother right after the birth of an Rh-positive baby to suppress antibody formation by the mother
What is RhoD immune globulin?
These 3 treatments are for patients who have a very high concentration of unconjugated bilirubin
What is exchange transfusion, albumin infusion, photo therapy ("bili lights")?
In adults, a systolic BP less than this value in mm Hg can mean that anaphylaxis is highly likely.
What is 90 mm Hg?
1 unit of RBCs raises Hct by this percentage
What is 3%
The approximate time range in which parasites can be seen in the blood after injection of malarial sporozoites
What is 12-30 days?