Week 1 & 2
Energy can be converted to different forms of energy, but it cannot be created or destroyed
What is the first law of thermodynamics?
Strongest type of bond
What is covalent?
The substance that binds a protein
What is a ligand?
The structural change that occurs when a ligand binds at a site other than the active site
What is allosteric regulation?
Blank do not affect the equilibrium point of a reaction
What is enzymes?
What level of protein structure is bonding of two or more polypeptide chains called subunits?
What is quartenary level?
The discrete unit in the protein that can fold independently
What is a protein domain?
Method that identifies conversed amino acids in related proteins and maps then onto a 3D structure to find binding sites
What is evolutionary tracking?
Can use to determine if a helix structure is amphilic?
What is a helix wheel?
ATP, NADHPH, Acetyl CoA, Carboxylated biotin, S-Adenosylmethionine, Uridine diphosphate glucose are examples of what in Metabolism?
Weak interactions that drive protein binding, including hydrogen bonds, electrostatics, and Van Der Waals forces
What are noncovalent bonds?
A reversible covalent modification that regulates protein activity and signaling
What is phosphorulation?
Helices that wrap around each other to minimize exposure of hydrophobic amino acid side chains to aqueous environment is called what?
What is a supercoil?
A base, a pentose sugar, and one or more phosphate groups make up what?
What is a nucleotide?
Type of domain that recognizes phosphotyrosine residues
What is the SH2 domain?
Proteins that switch between active and inactive state depending on whether GTP or GDP is bound
What is GTP binding proteins?
A substance that speeds up a chemical reaction without being used up in the process
What is a catalyst?
What is the direction that genetic information flows?
What is DNA to RNA to Protein?
Amino acid changes that can destroy a surface binding site
What is a conformational change?
Enzymes speed reactions mainly by stabilizing this high-energy, unstable configuration of the substrate
What is the transition state?