Glucocorticoids
Exogenous corticosteroids are absorbed in?
upper jejunum
which topical retinoid binds to all nuclear receptors?
Allitretinoin (ALL-receptors)
Foscarnet is the treatment of choice for?
Acyclovir-resistant HSV
antifungal that inhibits beta-1,3-d-glucan synthase?
echinocandins
Which Colombian singer is known for her BANGER song "Hips Don't Lie?
Shakira
What dose of prednisone is considered physiologic corticosteroid therapy?
5-7.5 mg/day
Retinoids bind 2 families of receptors - what are the 2 major retinoid receptors in KERATINOCYTES?
RXR-a, RAR-y (most abundant in the skin)
Valtrex can rarely cause what adverse effect in HIV patients?
TTP/HUS
MOA of allylamines/benzylamines
inhibits squalene epoxidase
Colombia produces 60% of the world's supply of which precious stone?
Emerald
What is the imaging test of choice to evaluate osteonecrosis in setting of CS use?
Bonus: what bone is most commonly affected?
MRI
Bonus: proximal femur
stop systemic retinoids when you notice this lab abnormality concerning for pancreatitis?
Bonus: highest risk of pancreatitis with which rx?
TG >800 mg/dL
Bonus: bexarotene
silver sulfadiazine
What is the mechanism of action of ketoconazole?
inhibits 14-a demethylase (catalazyes conversion of lanosterol to ergosterol)
Which mountain range spans through the country?
Andes Mountains
Alternate day (QOD) dosing decreases risk of nearly all major glucocorticoid complications EXCEPT (2)
1. cataracts 2. osteoporosis
we know isotretinoin is teratogenic duh... what is the most common malformation if iPledge fails?
cranial synostosis
topical azelaic acid may decrease pigmentation through what mechanism?
competitively inhibiting tyrosinase
Two- part question:
griseofulvin MOA is ___? AND is more effective than terbinafine in tinea capitis cause by ___?
1) intereferes with tubulin
2) Microsporum (M.canis)
How many stars does the Colombian flag have?
None! Amarillo, Azul, y Rojo!
Which enzyme converts steroids to their active form in the liver?
11B-hydroxysteroid dehydrogenase
cortisone --> cortisol
prednisone --> prednisolone
List the following retinoids from short to long half life - isotretinoin, etretinate, bexarotene, tretinoin, acitretin
*Double points if can specify half-life
tretinoin - 30 min - 2 hours
bexarotene - 7 hours
isotretinoin - 22 hours
acitretin - 48 hours
etretinate - 120 days
List tetracycline in order from most to least photosensitive
Demeclocycline > doxycycline > tetracycline > minocycline
drug-induced SCLE may be a rare AE of what anti-fungal?
terbinafine
Where was Bella born?
Evanston, Illinois