Genetic Mutations
The most common mutation which causes breast cancer (be specific)
What is the BRCA1 mutation?
The lower dose of tamoxifen approved for prevention.
What is 5mg.
The prospective trial which offered predictive information on ER+ node negative women with Oncotype score <26
What is TAILORx?
The drug that has shown superior CNS activity for untreated HER2+ brain mets in the HER2 CLIMB trial
What is tucatinib?
The percentage of triple negative breast cancer
What is 10-15%?
The indication for adjuvant abemaciclib
What is HR+ HER2-, node positive breast cancer at high risk of recurrence and Ki-67 >20%?
Preferred therapy for T1bN0M0 HER2+ breast cancer
What is Paclitaxel and Herceptin?
Carboplatin has been shown in multiple studies to improve this parameter in neoadjuvant TNBC treatment.
What is pathologic complete response?
Genetic mutation associated with breast, uterine, and thyroid cancer.
What is PTEN mutation?
Non-hyperplasia lesions which may be considered for removal (only need to name one).
What are radial scar and papilloma?
The new oral SERD Elacestrant is approved for which population?
Metastatic ER+ with ESR1 mutation, treated with AI
The other name for HER1 in the HER family
What is EGFR?
The trial which earned FDA approval for Pembro + chemo in neoadjuvant TNBC, regardless of PDL-1 expression.
What is KEYNOTE 522?
The subtype of breast cancer commonly associated with p53 mutation
HER2+ breast cancer
Three lifestyle modifications that have been proven to lower the risk of breast cancer.
What are maintenance of healthy body weight, alcohol moderation, and exercise?
The Index which measures response to neoadjuvant endocrine therapy, using tumor grade, Ki-67, ER, and other features?
Preferred first line metastatic HER2+ therapy
What is TPH (Docetaxel, Pertuzumab, Herceptin)?
The fourth receptor which may be positive in TNBC with apocrine features
What is androgen receptor?
Cancers associated with PALB2 mutation
Breast and pancreatic cancer
Name 2 categories of women who should get breast MRI's for surveillance
Mutation carriers
h/o mantle radiation
Lifetime risk >20%
The first trial which resulted in FDA approval of CDK 4/6 inhibitor in ER+ metastatic breast cancer.
What is PALOMA?
The drug:antibody ratio of trastuzumab-deruxtecan
Monoclonal antibody targeting TROP2 which can be used in 2nd line metastatic TNBC
What is sacituzumab?