MOA n PK
Binds ergosterol to form pores
What is Amphotericin B?
1st generation cephalosporins are good for treating these most common bacteria colonized on the skin
What are Staph and Strep?
Associated with tendon rupture
What are fluoroquinolones?
Switching to targeted therapy based on cultures and susceptibilities
What is de-escalation?
or What is tailoring therapy?
Candida species that is resistant to fluconazole
What is C. glabrata
Drug class with ~ 100% bioavailability that is known to accumulate in bone and teeth, causing teeth staining in children
What are tetracyclines?
Luminal antiparasitic agent safe in pregnancy
What is paromycin?
Chloroquine, mefloquine, primaquine, quinidine have this class adverse effect
What is QT-prolongation?
Antibiotic that strongly induces CYP enzymes
What is rifampin?
We pair antibiotics with this to prevent breakdown of the B-lactam ring
What is a beta-lactamase inhibitor combo
Inhibits cell wall synthesis but effective concentrations are only in the urine
What is fosfomycin?
Best penicillin for treatment of MSSA?
What is dicloxacillin, oxacillin, and nafcillin?
Reaction you get when mixing metronidazole and alcohol
What is a disulfiram-like reaction?
High serum troughs of these agents are associated with nephrotoxicity and ototoxicity
What are aminoglycosides?
and also
What is/are glycopeptides (or just vancomycin)?
Cefepime and ceftazidime are the two cephalosporins (aside from 5th generation) that cover which resistant organism?
What is Pseudomonas aeruginosa?
Inhibits beta 1,3 glucan synthase in cell membrane preventing cell wall synthesis
What are echinocandins?
or
What is micafungin, caspofungin or anidulafungin?
First-line for invasive Aspergillus
Azole antifungals
What is hepatotoxicity?
The lowest antimicrobial concentration that prevents growth of an organism
What is the MIC?
Or
What is the minimum inhibitor concentration?
Document of cultures and sensitivities that provides information to your institution/community about local resistance patterns
Inhibits microtubules in worms
Fluoroquinolones, macrolides and tetracyclines cover these type of organisms: Mycoplasma, Chlamydia and Legionella
What are atypicals?
Specific infection that occurs from overuse of antibiotics, especially clindamycin, fluoroquinolones and cephalosporins
What is C.diff?
or What is C. difficile?
We monitor weekly CPK levels due to risk of myopathy
What is daptomycin?
Carbapenems cover this major CDC threat organism:
What is an ESBL?
or
What is an Extended Spectrum Beta-lactamase Producing Organism?