Cancer Genetics and Genomics

Cancer Genetics

100

This is the process of transforming normal cells into malignant cells.

Carcinogenesis

200

These are identifiable risks that influences a patient's pre-disposition risk to cancer. Give me examples!

Non-Modifiable vs. Modifiable Risks

300

This is the phenomonen of cancer cells moving to other areas of the body. 

Metastasis

400

This terms refers to agents that can cause cancer. Give me examples!

Carcinogens

500

This is the process of looking at cancer cells underneath a microscope to determine their malignancy.

Grading

Cancer Mutations

100

True or False? When a cell sustains DNA damage, it is always cancerous. 

False

200

These cancers are caused by a combination of inherited and acquired mutations.

Hereditary cancers

300

This type of cancer is caused by the build up of acquired mutations.

Sporadic cancers

400

This mutation is associated with breast cancer and prostate cancer.

BRCA genes

500

This syndrome is associated with inherited colon cancer.

Lynch Syndrome

Cellular Basics

100

This is the functional unit of life. They are organized into tissues --> organs --> organ systems.

Cell

200

This genetic material is found in all human cells and stores information for living organisms

DNA (deoxyribonucleic acid)

300

This is where genetic data (DNA) is stored within the cell.

Nucleus

400

This is a sequence of DNA which functions as the basic unit of heredity passed from parent to child.

Gene

500

This molecule is a product from gene and functions to carry out the functions of the cells.

Protein

Cancer Genomics

100

This project lead to mapping and sequencing of the human genome.

Human Genome Project

200

True or False? Previous Oncology Treatments can increase the risk of cancer.

True

300

This kind of testing checks for one gene.

Single Gene Testing

400

This kind of testing tests for multiple genes.

Multi-Gene Panel Testing

500

These are drugs used to precisely identify and attack specific molecules and genetic changes for a person's cancer.

Targeted Therapy

Genomic Vendors

100

At Winship, we use the following genomic vendors:

Caris, Guardant, Signatera, Invitae & Oncotype

200

This genomic vendor analyzes cell-free DNA and RNA from plasma, plus genomic DNA and messenger RNA from circulating white blood cells (WBCs) to distingush mutations

Caris Assure

300

This Guardant test has a 5 day turnaround time. 

Guardant 360cdx

400

This genomic vendor is used for breast cancer

Oncotype

500

This genomic vendor tests for presence or absence of  molecular residual disease over time. 

Signatera