Stage 0
initiating apoptosis through death receptors or mitochondrial
What is extrinsic and intrinsic pathways?
Due to this mutation in this cancer cells continue to divide and avoid cell death
What is G1 and P53
The rapidly dividing cells that move deeper into the tissue and other organs
what is metastasizes
Cancer cells travel through this body system to reach other organs
What is epithelial cells
To achieve growth the tumor cells secrete proteins to stimulate blood vessels.
What is how tumor cells stimulate blood vessel growth as they expand
In between what stages does DNA go through apoptosis if damaged?
What is Between G2 and M
Resistance to apoptosis
What is the overexpression of anti-apoptotic protein
facilitate the breakdown of the matrix allowing cancer cells to invade the tissue
what is the role of enzyme matrix's
tumor cells weakly attaching and rolling along the vessel lining until securely attached
What is how tumor cells attach and enter new tissues?
, the formation of leaky and disorganized vessels in tumors, and the promotion of interaction between cancer cells and vascular endothelial cells
what is the role VEGF plays in creating new blood vessels?
in this phase of the cell cycle where cells can enter and exit and are not actively dividing
What is the G0 phase?
Caused by mutation what is being overproduced that helps initiate a cascade of events to regulate the cell cycle
What is ligands?
Tumor cells migrate toward the blood vessels they breakdown the basement membrane surrounding the vessels
What is tumor cells interaction with the extracellular matrix
entering the bloodstream and/or lymphatic system to initiate new tumors in other parts of the body
what is the tumor breaks from the main tumor
The prevention of endothelial cells that form blood vessels
what is targeting VEGF and its receptors to inhibit further spreading
This prevents uncontrolled cell division by halting the cell cycle.
what is p53?
mutation of this gene leads to abnormal activation of the signaling pathways they control
What is Proto-oncogenes
leaving an open pathway that allows for less aggressive cells to invade the tissue and grow
what is the aggression of the tumor cells?
mutation of this inhibits apoptosis and allows cancer cells to metastasize
what is CDKs
cell express proteins to allow the new blood vessels to form growth of new vessels in the tumor
What is new blood vessels facilitate continued tumor growth?
They push the cell cycle through acting as checkpoints
What is the role of CDKS
these genes act as brakes and when mutated remove the inhibition on cell division and growth
What is tumor suppressor genes
This begins the invasions of tumor cells causing the cells to spread and infect other parts of the body
what is loss of cell adhension
fight cancer by blocking the growth factor(VEGF) receptors from working by blocking the receptors
What is monoclonal antibodies?
Proliferation of the blood vessels can induce
what is the breakdown of the extracellular matrix