Is that my bones that hurt?
Why do I feel worse?
All clogged up...
A small marker on the map
Therapy Grab-Bag
100

The tissue type of origin for sarcomas & the 2 categories in which they fall

Mesenchymal / Bone & Soft Tissue

100

Cancer patient on high-intensity chemotherapy with a new fever >100.4F

Neutropenic Fever - look for Neutropenia of <500

100

The most significant risk factors for squamous cell carcinoma of the head and neck (list 2)

Alcohol & Tobacco

100

The mutation that confers resistance to antibody therapy in colorectal cancer

KRAS

100

The extent to which a tumor has spread

Staging

200

Sunburst pattern seen on bone radiograph

Osteosarcoma

200

Skin condition over the trunk, scalp, and face associated with anti-EGFR chemotherapy

Anceiform Eruption - treat with topical steroids

200

Condition commonly found with: JVD, facial edema, cyanosis; made worse by leaning forward or lying down (and list the 2 most common causes)

Superior Vena Cava Syndrome - Lung cancer & Mediastinal tumor

200

Tumor marker that, with imaging, negates the need for a biopsy to diagnose hepatocellular carcinoma

alpha-fetoprotein

200

The cell phase(s) most susceptible to radiation therapy

M & G2

300

Genetic mutation causing cancer that appears as onion-peeling on radiograph (and diagnosis)

t(11:22) - Ewing Sarcoma

300

2nd leading cause of death in cancer patients, no matter how Virchowous they are

Thromboembolic Events

300

Causative organisms for: (1) oropharyngeal & (2) nasopharyngeal squamous cell carcinomas (name both)

(1) HPV / (2) EBV
300

CD45 & CD20 (name the broad type of cancer)

Lymphoma

300

The most effective pair of medication classes in chemo-induced N/V (2 classes)

Seratonin Receptor Antagonists (ondansetron) & Neurokinin-1 Receptor Antagonist (Aprepitant)

400

Known cancer patient now presenting with weakness in both legs but sensation remains intact - Diagnosis & site of origin (multiple correct answers)

Cauda Equina Syndrome (spinal cord compression); Breast, Lung, Prostate, Multiple Myeloma

400

The most important anatomic feature that results in complications from Vena Cava Syndrome

Azygous Vein - compression below this level does not allow for development of collateral veins, causes increased congestion

400

Iodine-125 is great for radiation therapy in the early stages of which cancer?

Prostate Cancer

400

S100 & HMB45

Melanoma

400

The gold standard for measuring efficacy of cancer drug therapy

Survival time / Disease-free survival time

500

Bone pain, nausea, constipation, serum calcium 11.3, new diagnosis of nephrolithiasis...

Primary Hyperparathyroidism... Then consider malignancy (squamous cell carcinoma of the lung, multiple myeloma, breast cancer)

500

Prophylactic drug therapy for high-intensity leukemia chemotherapy to prevent an oncologic emergency... name (1) the drug, (2) the disease process prevented, and (3) the lab findings associated with it

Allopuruinol or Rasburicase; Tumor Lysis Syndrome; Hyperuricemia, Hyperkalemia, Hyperphosphatemia, Hypocalcemia

500

Risk stratification done using the Khorana Score (may also see this condition in pregnancy, when starting birth control, or after long plane rides)

Cancer-associated Thrombosis

500

p16-INK4a

HPV associated oropharyngeal cancer

500

FOLFOX Treatment Regimen (with diagnosis)

5-Fluorouracil (antimetabolite, folate cycle); Leucovorin (prevents toxicity of antifolate drugs), Oxaliplatin (DNA cross-linking)