Glycogen can be found in our skeletal muscle tissues and blood
True
False
False; primarily found in the muscles and liver
What is the primary enzyme of glycogenolysis?
a. Branching Enzyme
b. Glycogen Synthase
c. Glycogenin
d. Glycogen Phosphorylase
d. Glycogen Phosphorylase
Which of the following is not a product of glycolysis?
2 pyruvate
1 FADH
2 NADH
2 ATP
1 FADH
Fill in the blank.
The net ATP yield of glycolysis is
The net ATP yield of oxidative phosphorylation is
glycolysis - 2
oxidative phosphorylation - 32-36
What enzyme begins the breakdown of starch digestion in the mouth
Alpha-dextrinase
Lactase
Alpha-amylase
Sucrase
Alpha-amylase
What is the primer for glycogenesis?
Glycogenin
Which of the following steps in glycolysis involves an irreversible reaction?
Step 2
Step 5
Step 7
Step 10
Step 10
Which of the following proteins is directly responsible for producing cyclic AMP (cAMP) in response to receptor activation?
A) Phospholipase C
B) Adenylyl cyclase
C) Protein kinase A
D) GTPase-activating protein (GAP)
B) Adenylyl cyclase
SURPRISE!! It's a cyclic-AMP cascade question
How does the cyclic-AMP cascade affect the rate of glycogenolysis?
DOUBLE: Which of the following answer options BEST describes the sequence of steps in the cyclic AMP (cAMP) cascade for regulating glucose production?
a) Glucagon binds to receptors → adenylate cyclase is inhibited → cAMP levels decrease → protein kinase A (PKA) is activated → glycogenolysis is accelerated.
b) Glucagon binds to receptors → adenylate cyclase is activated → cAMP levels increase → protein kinase A (PKA) is activated → glycogenolysis is accelerated.
c) Insulin binds to receptors → adenylate cyclase is activated → cAMP levels increase → protein kinase A (PKA) is inhibited → glycogenolysis is slowed down.
d) Lactate stimulates cAMP production → protein kinase A (PKA) is activated → gluconeogenesis is inhibited.
Increases, or speeds it up
DOUBLE: b) Glucagon binds to receptors → adenylate cyclase is activated → cAMP levels increase → protein kinase A (PKA) is activated → glycogenolysis is accelerated.
How does exercise affect the rate of glycogenolysis?
a. increase
b. decrease
c. stays the same)
DOUBLE: What happens to the rate of glycogenesis during exercise?
increase
DOUBLE: decrease, glycogenesis will be inhibited (or turned off) during exercise as there is little need to glycogen building activities
Where does the process of mainstream glycolysis take place (meaning where are we in the cell when we end with 2 pyruvate)?
Mitochondria
Cytosol
Smooth endoplasmic reticulum
ribosome
DOUBLE: How is aerobic glycolysis different? And how do we move into the mitochondrial membrane
Cytosol
DOUBLE: Aerobic glycolysis requires oxygen and travels from the cytoplasm into the mitochrondria. We are able to move into the membrane through the conversion of pyruvate into acetyl CoA by decarboxylation.
What is the difference in ATP yield between anaerobic glycolysis and aerobic glycolysis?
Anaerobic glycolysis yields 2 ATP, while aerobic glycolysis yields 30 ATP
Anaerobic glycolysis yields 30 ATP, while aerobic glycolysis yields 2 ATP
Both anaerobic and aerobic glycolysis yield the same amount of ATP, which is 15 ATP
There is no difference in ATP yield between anaerobic and aerobic glycolysis
DOUBLE: What happens to the fate of pyruvate during anaerobic glycolysis?
Anaerobic glycolysis yields 2 ATP, while aerobic glycolysis yields 30 ATP
DOUBLE: Gets converted into lactate
What is the final end product of carbohydrate digestion and where are they distributed?
Monosaccharides (glucose, fructose, and galactose)
Distributed through blood capillaries to be sent to the liver where it can later be distributed to muscle cells for energy
Describe the difference between glycogenesis and glycogenolysis.
glycogenesis - formation of glycogen for storage in liver and muscles
glycogenolysis - breakdown of glycogen to release glucose
Explain why the net ATP production of glycolysis is 2.
The net ATP production of glycolysis is 2 because it cancels out the 2 ATP molecules it invested at the start during the payoff phase.
Name the rate limiting enzyme for the Krebs cycle, ETC, and glycolysis.
Isocitrate dehydrogenase, cytochrome oxidase (complex IV), and PFK
What type of proteins help move these sugars into
the cells.
transport proteins
Which of the following enzymes is MOST directly involved in glycogenesis?
a) Fructose 1,6-bisphosphatase
b) Phosphofructokinase
c) Glycogen phosphorylase
d) Glycogen synthase
d) Glycogen synthase
How many NADH's are collected from the Krebs cycle
3 NADH molecules
Which hormone is responsible for starting the cyclic-AMP cascade?
Epinephrine