Jillian Barry
PNS - no clean jokes.
Demyelination for Days
Sell the Pharm
For King and Country
100
A common and often devastating complication of GBS - occurs when ascending paralysis affects corresponding life-giving muscles.
What is respiratory failure?
100
Around day 16 of gestation, this line forms on the developing embryo.
What is the primitive streak? Bonus 100: Define the axis the streak forms along and name the cell type involved in proliferation and migration (resulting in the streak).
100
Demyelinating disease defined by Vitamin B12 deficiency.
What is Subacute Combined Degeneration of the spinal cord? For 100 bonus points: Name the three tracts affected.
100
Bulk-forming laxative, soluble fibers increase water absorption in the intestinal lumen - this medication stretches the bowel wall and leads to stimulation of peristalsis.
What is Psyllium (Metamucil)?
100
The second Tudor monarch - led the English Reformation to separate from the Roman Catholic Church.
Who is Henry the VIII?
200
This term describes the common laboratory findings associated with GBS, namely CSF with a high protein level and normal WBCs.
What is albuminocytologic dissociation?
200
The term for the lateral cells of the neural folds excluded from neural tube development, which ultimately give rise to the PNS (PNS, spinal, cranial nerves).
What are neural crest cells? Bonus 100: Tell the class what the neural tube develops into and the system to which the final structure belongs.
200
Late-stage syphilis defines this disease.
What is Tabes Dorsalis? For 100 bonus points: Name the affected areas/parts of the CNS.
Note - Treated with penicillin.
200
Medication that modulates the function of B/T lymphocytes, neutralizes pathogenic autoantibodies and interferes with antigen presentation - isolated from 1000s of donors.
What is Intravenous Immunoglobulin (IVIG)?
200
This man ruled the Macedonian Empire in ancient Greece - succeeded his father Philip II and led extended military campaigns throughout Asia and Northern Africa.
Who is Alexander the Great?
300
Often confused with GBS, this diagnosis should be considered if the course of symptoms takes more than 8 months, or if relapse occurs 3 times.
What is Chronic Inflammatory Demyelinating Polyneuropathy?
300
While CNS and not PNS, these two plates develop into the ventral and dorsal portions of the spinal cord, respectively.
What are the basal (ventral) and alar (dorsal) spinal plates? Bonus 50: Which is motor and which is sensory?
300
Demyelination in the CNS secondary to infection of oligodendrocytes by JC virus defines this virus.
What is Progressive Multifocal Leukoencephalopathy? For 100 bonus points: CD4 count is expected to be <____ in this disease?
300
Class of drug which inhibits parietal cell H+/K+ ATP pump and suppresses gastric basal and stimulated acid secretion. (will also take an example/suffix)
What is a PPI, omeprazole, -prazole?
300
This man was exiled to the remote island of St. Helena.
Who is Napoleon Bonaparte?
400
This fraction of patients with GBS experienced upper respiratory or GI tract infection up to six weeks prior to onset of symptoms.
What is 2/3?
400
This inherited disease affecting Schwann cell development, structure, and function commonly results in distal muscle weakness and atrophy, reduced or absent reflexes, sensory deficits, and is associated with scoliosis and foot deformities (hammer toe, pes cavus).
What is Charcot-Marie-Tooth disease? For 100 bonus points: Name the most common modality of inheritance.
400
Defined by massive axonal demyelination in pontine white matter secondary to rapid sodium changes, most commonly iatrogenic correction of hyponatremia (could also be other osmolytes like glucose).
What is Osmotic Demyelination Syndrome (also known as Central Pontine Myelinolysis)?
Note - From low to high (Na+), your pons will die (ODS). From high to low, your brains will blow (herniation).
400
Class including Enoxaparin (Lovenox). Describe the mechanism of action for a bonus 300.
What is an Anticoagulant (Low Molecular Weight Heparin)?
See explanation.
400
Known for uranium production - Chad to its east, Mali to its west.
What is Niger?
500
The most common subtype of GBS.
What is acute inflammatory demyelinating polyneuropathy (AIDP)?
Note - Autoantibodies directed at myelin membrane. Pain and CN involvement are more common in this subtype.
500
The most common type of neural tube defect.
What is spina bifida?
500
This disease is defined by autoimmune demyelination of CNS, an average onset of 30 years, and this finding in the CSF. (Must get both answers!)
What are Multiple Sclerosis and oligoclonal bands?
500
In cases of Anti-Myelin Associated Glycoprotein (MAG) neuropathy (PNS demyelination), treatment with this drug is appropriate when the patient presents with sensorimotor weakness.
What is Rituximab?
500
Many of the tourists flocking to this country northwest of Panama visit the national park named for Irazu volcano.
What is Costa Rica?