Myelofibrosis
AML
MDS
ET
PCV
100
This specific mutation is associated with Myelofibrosis
(V617F) JAK2
100
AML is diagnosed when myeloblasts make up at least this percentage of cells in the blood or bone marrow.
What is 20%?
100
Neutrophils with bilobed nuclei and hypogranular cytoplasm are called these cells.
What are pseudo-Pelger Huet Cell?
100
ET requires a sustained platelet count at or above this value, after reactive causes such as iron deficiency are excluded.
What is 450,000 u/L?
100
PV patients itch after a hot shower because of histamine released from these cells.
What are mast cells?
200
What is the name of this common cell finding on Myelofibrotic blood smears?
What is a dacrocyte?
200
The major goal of flow cytometry in suspected AML is to separate it from this other acute leukemia, because treatment differs significantly.
What is acute lymphoblastic lymphoma (ALL)?
200
In MDS, premature death of precursors inside the marrow causes cytopenias despite a hypercellular marrow, a concept called this.
What is ineffective hematopoiesis?
200
Mutation is found in half of ET cases
What is JAK2 (V617F)?
200
Levels of this are typically low in PCV patients
What is EPO?
300
Marrow fibrosis in PMF gives a "dry tap" and pushes blood production to these two organs.
What are the liver and spleen?
300
In children under 5 with trisomy 21, this AML subtype, named for the platelet-producing lineage, is classically seen.
What is acute megakaryoblastic leukemia?
300
Prussian blue stain highlights these iron-laden erythroid precursors, caused by defective incorporation of iron into heme.
What are ring sideroblasts?
300
The majority of ET cases present with this symptom
What is asymptomatic?
300
The bone marrow in PCV shows hypercellular marrow trilineage proliferation. This phenomenon is referred to as
What is panmyelosis?