Receptor? I barely know 'er!
NMDA and AMPA receptors are an example of this type of receptor that itself forms an ion channel
Ionotropic Receptors
This refers to a short-term increase in excitability due to accumulation of Ca2+ in the presynaptic terminal from repeated stimulation
Facilitation
What is the effect of lowering extracellular Ca2+ on spike frequency adaptation?
Lowering extracellular Ca2+ reduces spike frequency adaptation?
The Nernst equation can be used to solve for this value for a given ion where the rate of influx is equal to the rate of ion efflux
Equilibrium Potential
This type of cell-cell communication involves the direct passage of ions between cells without the release of neurotransmitters
Electrical synapses
This type of channel has a mixed cation conductance and underlies the EPP at the neuromuscular junction
nAchR (nicotinic acetylcholine receptors)
The projections from CA3 to CA1 hippocampal pyramidal neurons are known as ________
Schaffer collaterals
Silent synapses contain which type of receptors?
NMDA only
This is the value at which the net current through a given ion channel is zero (inward current reverses to outward current)
Reversal potential
Full fusion of NT-containing vesicles to the presynaptic membrane alters this membrane property
Whole-cell capacitance
Stimulation of this Gs GPCR in myocardial cells increases cAMP, allowing for the activation curve of HCN channels to shift to positive potentials
beta-adrenergic receptors
Short-term decrease in EPSP amplitude is known by this term
Short-term depression
What are the two ways LTP is facilitated through AMPA receptors?
Increased AMPA insertion into the membrane + phosphorylation of existing AMPA receptors to increase their conductance
What are some main differences between action potentials and postsynaptic potentials?
PSPs are graded, with variable amplitude and time courses, are subthreshold, and can be depolarizing or hyperpolarizing.
APs are all-or-nothing, always depolarizing, and have a stereotyped amplitude and time course, with a refractory period that limits firing frequency.
This class of proteins is involved in binding vesicles to the presynaptic membrane, and can be blocked by botulinum toxins.
SNARE proteins
This Gq GPCR receptor class has glutamate as its ligand and triggers the release of Ca2+ from intracellular stores
mGluR (metabotropic glutamate receptors, specifically mGluR 1 and 5)
This is the process by which repeated exposure to a stimulus results in a decreased neuronal response
Habituation
Induction of LTP3 requires the phosphorylation of CREB and what other cellular process?
Opening of voltage-gated calcium channels on the postsynaptic side
This kind of potential is produced at the neuromuscular junction when neurotransmitter-containing vesicles spontaneously fuse to the membrane at the presynaptic terminal
MEPPs
This refers to the number of quanta involved in an evoked synaptic response
Quantal content
Activation of this receptor by norepinephrine inhibits further release of neurotransmitter by closing N-type Ca2+ channels
alpha-adrenergic receptors (Go GPCR)
Deletion of CaMKII has what effect on LTP
Deletion of CamKII blocks induction of LTP
Ryanodine receptors, NMDA receptors, CaMKII, and voltage-gated calcium channels are involved in which type of synaptic plasticity?
LTP1
Activation of the GIRK channel has what effect on membrane potential?
Activation of the GIRK channel makes the Vm more negative (hyperpolarized)
This protein interacts with intracellular Ca2+ to bind a neurotransmitter-containing vesicle to the presynaptic membrane
Synaptotagmin