Adaptive Immunity
Adaptive/innate Immunity
Innate Immunity
Innate immunity
Inflammation
100
How does the PRR recognize an "foreigner" on a pathogenic organism?
What is PAMP
100
Substances that are recognized as foreign or non-self
What is an antigen
100
Mucous membranes protecting the skin and the membranous sheets lining the GI, GU and respiratory tract are examples of
What is Physical barriers
100
Vasoactive amine released during mast cell degranulation that causes temporary rapid constriction of large vessel walls and dilation of the post capillary venules, both of which increases flow to the microcirculation
What is histamine
100
Describe (briefly) the benefits of inflammation
Prevents infection, further microbial damage
limits/controls inflammatory process
interacts with components of adaptive ImSys
prepares area for repair
200
Serum glycoproteins or immunoglobulins produced by plasma cells in response to an antigenic challenge
What is an antibody
200
The hepatitis B vaccine is a form of
What is active immunity (HBsAG)
200
Biochemical substance that Attracts leukocytes to the site of inflammation
What is chemotactic factor
200
Predominant Phagocytic cells in early inflammation
What is a Neutrophil
200
What are the hallmark features of acute inflammation
edema
neutrophils
300
Most abundant class of immunoglobulins, constitute 80-85% of those circulating in the body and account for most of the protective activity against interactions
What is IgG
300
Immunity passed from mother to offspring is a form of
What is passive immunity
300
Three key plasma protein systems that are essential in order to have an effective inflammatory response
What are the complement system, the clotting system and the kinin system
300
These phagocytic cells are the body's primary defense against parasites
What is Eosinophil
300
Name 2 catagories/causes of acute inflammation
Infectious
Tissue necrosis/injury
400
Name the granulocytes & describe where they are located
What is BEN M:
Baso - blood
Eo - blood/tissue
Neutro blood/tissue
Mast - tissue
400
What is the central cell of inflammation
what is the Mast cell
400
This system is a group of plasma proteins that forms a fibrous meshwork at an injured or inflamed site and prevents prevents the spread of infection to adjacent tissue, trap microorganisms and foreign bodies at the site of inflammation for removal by infiltrating cells, forms a clot that stops bleeding and forms a framework for future repair and healing
What is the clotting system
400
Part of the innate immune system, these cells act against tumors, virally infected cells and obligate intracellular pathogenic organisms (like bacteria).
Name the type of cell, mechanism of action and what this will lead to
What is Natural Killer Cell & Tc
Recognize abnormal cell signalling molecules on self cells (ie red flags) --> secrete granules onto infected/tumor cell --> cell is signaled to enter apoptosis
400
Name or draw a concept map of the mediators of acute inflammation
500
Name the 5 immunoglobulin classes. Which can cross the placenta? Which are found in mucus?
Bonus: Group of genes that code for protein found on the surface of the cells that help the immune system recognize foreign substances, Its like the cells "ID badge" is responsible for determining compatibility of donors for organ transplant
IgG, IgM, IgA,IgE, IgD
IgG cross placenta/are in breast milk
IgA are in mucus and breast milk
*all forms of Abs have been found in breast milk but the largest concentration is IgA
What is the Major histocompatibility complex
500
What are the systemic manifestations of inflammation
what is fever, leukocytosis, increased plasma protein synthesis
500
Name the 5 substances secreted by mast cells that initiate inflammation (via degranulation)
What is histamine, chemotatic factors, prostaglandins, leukotrienes, PAF
500
Local manifestations of cancer resulting from vascular changes and corresponding of circulatory components into the tissue are
What is heat, redness, swelling and pain
500
Name 7 cellular receptor involved in acute inflammation
PRR PAMP DAMP
TLR Complement Scavenger
NOD-like