Ch.6 Adrenergic Bronchodilators

Quiz Questions Part 1

100

Adrenergic bronchodilators mimic that actions of

Epinephrine

200

Disease states that could benefit from the use of adrenergic bronchodilators

asthma, bronchitis, emphysema, bronchiectasis, Cystic Fibrosis

300

Your patient is diagnosed with persistent asthma. Which type of drug would you recommend for maintenance bronchodilation and control of bronchospasm?

long-acting adrenergic agent

400

A pediatric patient presents with the classic “barking cough” found with laryngotracheobronchitis (croup). What drug would you recommend to provide relief from subglottic swelling?

racemic epinephrine

500

The single (R)-isomer of albuterol is named

Levalbuterol

Quiz Questions Part 2

100

The bronchodilating action of adrenergic drugs is due to stimulation of

B2 receptors

200

What type of drug is Salmeterol?

a long-acting B-adrenergic

300

What route of administration is unsuitable for Catecholamines?

oral

400

The larger the side-chain attachment to a catechol base, the greater is the B2 specificity is known as what?

The keyhole theory

500

Indications for Epinephrine

Severe allergic reaction (systemic hypersensitivity reaction, acute asthma episode, cardiac stimulation

Short-Acting Agents

100

Short-acting B2 agonists (SABA) are indicated for

relief of acute reversible airflow obstruction

200

Short-acting agents are considered “_____” agents

rescue

300

2 Brand names for Albuterol

Proventil and Ventolin

400

Brand name for Levalbuterol

Xopenex

500

Albuterol is available in the following forms

syrup, nebulizer solution, MDI, oral tablets

Long-Acting Adrenergic Agents

100

Name 3 long-acting adrenergic agents

Formoterol (Performist), Salmeterol (Serevent), Arformoterol (Bravana)

200

Long-acting B2 agonists (LABA) are indicated for

maintenance therapy for asthmatics

300

The main difference between Salmetoral and Formotoral

Formotoral has a quicker onset and peak effect than Salmetoral

400

Arformotoral dosage and route

15mcg BID via nebulization

500

ultra-long-acting B-agonist approved for the treatment of COPD

Olodaterol (Striverdi Respimat)

Random Highlights

100

Inhalation is the preferred route of administering adrenergic bronchodilators for the following reasons:

Rapid onset of action Smaller doses used Reduced side effects Drug delivered directly to the target organ Relatively safe and painless route

200

B1-Receptor stimulation causes

increased myocardial conductivity, heart rate, and contractile force

300

Smooth muscle relaxation most likely occurs as a result of

an increase in intracellular cAMP

400

A patient on their third continuous neb of albuterol (15 mg/hr) may experience the following complications:

Hypokalemia Cardiac arrhythmias Premature ventricular contractions Hyperglycemia Tremors

500

Stopping the treatment may be warranted if

If the patient’s heart rate increases by greater than 20% from its pretreatment rate