Age group that metabolizes some drugs more rapidly that adults.
What are children?
100
Decreased hepatic metabolism and drug elimination, the condition causes the skin to turn yellow.
What is cirrhosis?
100
Hepatitis and hepatic necrosis is part of this toxicity.
What is hepatotoxicity.
100
Drugs that form nonabsorbable complexes by binding to other drugs.
What is complexation?
100
Interactions that alter drug absorption can be minmized by separating the food and drug in take, by what.
What is 2 hours
200
Age group that has slow distribution of drug molecules due to decreased cardiac output.
What are the elderly?
200
This is the major plasma protein in the body?
What is albumin?
200
A potentially fatal adverse reaction to a drug.
What is anaphylactic shock?
200
One drug can displace another from a plasma protien binding site and increase the amount of free drug available for distribution.
What is displacement?
200
This is found in age cheese, wine, beer, yeast products and can react with certain drugs, especially MAO inhibitors.
What is tyramine?
300
Group with drug responses related to hormonal fluctuation during menstral cycles.
What is gender?
300
With renal failure this organ will allow albumin to be filtered out.
What is kidney?
300
A drug than can cause cancer.
What is carcinogenic?
300
A drug that antagonizes the toxic effect of another drug.
What is antidote?
300
Metabolism can be increased with this diet.
What is high protein, low carbohydrate diet?
400
The largest contributing factor to inherited variability.
What is metabolism?
400
The bioavailability of drugs such as digoxin are increased with this disease state.
What is hypothyroidism?
400
An unexpected reaction to a drug the first time it is given.
What is idiosyncracy?
400
When one drug with no inherent activity of its own increases the activity of another drug that produces and effect.
What is potentiation?
400
Iron will interfer with this antibiotic.
What is tetracycline?
500
A field of study which defines the hereditary basis of individual differences in the ADME processes.
What is pharmacogenetics?
500
With renal failure the dosage of drugs should be ________.
What is decreased?
500
An abnormal sesnitivity generally resulting in an allergic reaction.
What is hypersensitivity?
500
When two drugs with similar pharmacological actions produce greater effects than the sum of the individual effects.
What is synergism?
500
A high fat diet can increase this substance which can displace previously bound drugs and increase the free concentration of that drug, leading to an increased effect.