MOA
This medication is converted to dopamine in the brain to replace depleted levels.
What is levodopa?
This medication is considered the gold standard for motor symptom control in Parkinson’s disease.
What is carbidopa-levodopa?
These involuntary movements are common with long-term levodopa use.
What are dyskinesias?
Patients taking levodopa should avoid taking it with this supplement because it reduces absorption.
What are iron salts?
This medication crosses the blood-brain barrier to convert into dopamine to alleviate symptoms of Parkinson's disease.
Levodopa should not be used with this class of antidepressants due to hypertensive crisis risk.
What is levodopa?
What are MAOIs?
This MAO-B inhibitor prevents breakdown of dopamine in the brain.
What is rasagiline? (or selegiline)
This medication is used for tremor-predominant early Parkinson’s disease.
What is benztropine? (anticholinergic)
This serious liver complication is associated with tolcapone.
What is hepatoxicity?
Patients on MAO-B inhibitors {Safinamide,Selegiline} should avoid this herbal supplement.
What is St. John’s Wort?
These medications are primarily metabolized in the liver and excreted in urine.
What are dopaminergic agents?
This COMT inhibitor increases levodopa duration but does NOT cross the blood-brain barrier.
What is entacapone?
These medications are added when patients experience “wearing-off” effects of levodopa.
What are COMT inhibitors? (entacapone, tolcapone)
These classic peripheral side effects occur with anticholinergics.
{Benztropine, Diphenhydramine, Trihexyphenidyl}
What are dry mouth, blurred vision, constipation, and urinary retention?
This population requires lowest effective doses of anticholinergics due to cognitive risk and urinary
retention.
Who are elderly patients?
This adjunctive agent medication does NOT cross the blood-brain barrier and is used with carbidopa–levodopa to increase the plasma concentration and
duration of action of levodopa by preventing its peripheral breakdown.
What is entacapone?
These drugs restore dopamine-acetylcholine balance by blocking muscarinic receptors.
What are anticholinergics? (ex: benztropine, trihexyphenidyl)
This drug has dual action: MAO-B inhibition and glutamate modulation.
What is safinamide?
This dangerous reaction can occur if MAO-B inhibitors are combined with tyramine-rich foods.
What is hypertensive crisis?
Pharmacokinetics of these medication cause it to cross the placenta and enter breast milk
What are Anticholinergic Agents?
This condition is an absolute contraindication for anticholinergic therapy. {Benztropine,Diphenhydramine,Trihexyphenidyl}
What is narrow-angle glaucoma?
This COMT inhibitor crosses the blood-brain barrier and carries hepatotoxicity risk.
What is tolcapone?
This antiviral medication is sometimes used to reduce dyskinesias.
What is amantadine?
Constipation risk related to what class of medicat
dopaminergic effects
These are the goals of drug therapy for a patient with Parkinson’s Disease.
What is Maintain ability to perform activities of daily living and managing minimize symptoms?
Dopaminergic Medication should be used with caution with this psych disorder.
What is psychosis?