Characteristics
MDMA
What year was MDMA first created?
1912
What is the word used to describe the state of openness and comfort MDMA users often experience?
Euphoria
What do users do to try and combat having an overdose from MDMA? (Name one)
Drinking large amounts of water; keeping a low room temperature
The main substitutes of MDMA, much like MDMA, can be classified as what?
Entactogens
What are the three hallmark signs of ecstasy usage?
Hyperthermia, hypertension, and tachycardia
What year was MDMA first scientifically tested, and by who?
1953; US Army
Based on its characteristics, is MDMA described as an addictive chemical? Yes or no?
No
True or False: Taking SSRIs with MDMA is ok to do
False
What are the main two substitutes for MDMA?
Methylone and Mephedrone
Orally via tablets
What type of "parties" was MDMA popular at, and where did it get its start in this setting?
Raves; United Kingdom
What three neurotransmitters does MDMA usage affect? Which is MDMA best at releasing?
Dopamine, Norepinephrine, Serotonin; Serotonin
SSRI usage early after MDMA usage can trigger what condition in the brain?
"Serotonin Syndrome"
The two main substitutes for MDMA are derivatives of what?
Cathinone
What was another side effect of ecstasy usage that has the opposite effect on a person as cannabis would?
Suppression of appetite
Aside from recreational use, what was the initial thought behind using MDMA in the clinical setting?
That patients would be more apt to open up about their problems in psychotherapy and thus the provider could gain more insight
Which neurotransmitter specifically contributes to the hyperthermic effect of MDMA use?
Dopamine
What amino acid causes the "down" after MDMA usage and is typically combated with SSRIs?
Tryptophan
What are the three piperazine drugs?
mCPP, TFMPP, BZP
What does MDMA stand for?
Methyldioxymethamphetamine
What was the initial creation of MDMA classified as?
A synthetic intermediate
ADH; Concentrates urine and retains water causing hyponatremia
Name one other drug that was listed on the slide that has similar effects that MDMA has at high doses.
Amphetamines; morphine
Which combination of the piperazine drugs mimic the effects of MDMA?
BZP and TFMPP