Chemotherapy

Mechanism of Action

100

Opdivo (Nivolumab)

What is PD-1 Inhibitor?

200

Udenyca, Nyvepria, Neulasta (peg-filgrastim)

What is granulocyte colony-stimulating factor?

300

Herceptin, Kanjinti, Ogivri (Trastuzumab)

What is inhibiting HER2 receptor?

400

Avastin, Zirabev, Alymsys (Bevacizumab)

What is a VEGF inhibitor?

500

Darzalex (Daratumumab)

What is targeting CD-38?  (expressed on malignant multiple myeloma cells)

Tumor Lysis Syndrome

100

List 4 of 5 lab values that can be abnormally high

What are potassium, phosphorus, creatinine, LDH and uric acid?

200

This electrolyte is abnormally low

What is calcium?

300

These are the most common ways of preventing tumor lysis

What are aggressive hydration, rasburicase, or allopurinol?

400

This is the most common culprit for tumor lysis syndrome

What is Burkitt's lymphoma?

500

The two black box warnings on rasburicase

What are development of methemoglobinemia and exacerbation of G6PD deficiency?

Side Effects

100

Nausea, vomiting, hair loss, myelosuppression

What is almost every single drug???

200

Cold sensitivity 

What is Oxaliplatin?

300

Neuropathy (Name 5 of 10 possible drugs)

What are Platinum-based (Oxaliplatin, Carboplatin and Cisplatin) Taxanes (Paclitaxel and Docetaxel), and Bortezomib (Velcade), Vinca Alkaloids (Vincristine and Vinblastine), Lenalidomide, Etoposide

400

Cardiomyopathy and mucositis

What are the anthracyclines?

500

Hypertension, Proteinuria, Bleeding

What is Bevacizumab (Avastin, Zirabev, Aymlsys)?

Supportive Care

100

The first-line drug for PCP prophylaxis

What is Bactrim?

200

Three most common premeds used for treatment (name the drug class)

What are corticosteroids, antihistamines, and antiemetics?

300

Infusion Regimens that typically include Bendaryl (name 5 of 7)

What are Rituximab, Trastuzumab, Cetuximab, Daratumumab, Doxil, Paclitaxel and Docetaxel

400

These drugs keep your patient from vomiting...hopefully (name 4 of 8)

What are ondansetron (or any 5-HT3 antagonist), antihistamines, benzodiazepenes, aprepitant, dexamethasone, Reglan, compazine, etc?

500

Infusion Regimens that typically include Bendaryl (name 5 of 7)

What are Rituximab, Trastuzumab, Cetuximab, Daratumumab, Doxil, Paclitaxel and Docetaxel

Side Effects (yes, there are a lot of them!)

100

Nephrotoxicity and ototoxicity

What is cisplatin?

200

-itis's (Pneumonitis, Hepatitis, Nephritis...)

What is immunotherapies?

300

Hyperglycemia, hypertension, immunosuppression, mood changes, weight gain

What are corticosteroids?

400

Hand-foot syndrome, mucositis

What is 5FU?  (Hand = FU)

500

Risk of secondary malignancy (especially AML)

What is etoposide?