Intro to Cancer Therapy
Goals of Cancer Therapy
Drug Classifications
More Drugs
Fundamentals of Administration
100
Staging system used to determine prognosis, treatment, and options for clinical trials.
What is TNM: Tumor location and size, Nodal involvement, Metastasis to distant locations.
100
4 goals of cancer therapy.
What is prevention, cure, control, and palliation.
100
Nephrotoxic, Acute and delayed Nausea (highly emetogenic), ototoxicity, and peripheral neuropathies.
What is Cisplatin
100
Hypersensitivity Test Dose prior to 1st dose w/ NHL patients. Pulmonary toxicity and lifetime dose limit of 400 units. PFTs recommended at initiation and every 1-2 months after
What is Bleomycin
100
Only necessary when splashing of a chemotherapy drug is possible i.e. IV Push, IP chemo.
What is eye and face protection
200
The 5 treatment modalities in cancer therapy.
What is surgery, radiation therapy, chemotherapy, hormonal therapy, and biotherapy.
200
Use of one or more treatment modalities prior to the primary treatment.
What is Neoadjuvant treatment.
200
Vitamin supplementation protocol used to reduce toxicities, (folic acid, vitamin B12, dexamethasone)
What is pemetrexed (Alimta)
200
Less toxic than non-liposomal form. Can cause hand-foot syndrome. Only use with D5W.
What is Doxorubicin Liposomal (Doxil)
200
Chemotherapy bags, tubing, transport bag, PPE to be disposed of in
What is Yellow Cytotoxic Chemotherapy Bin
300
The nurses 2 main roles in preparation for administering treatment as part of a Clinical Trial.
What is (1) verify patient has given informed consent and original is in the chart, and (2) ensure patient understands that participation is voluntary with the right to withdrawl at anytime.
300
Treatment strategy that reduces the possibility of drug resistance by using drugs that have different mechanisms of action.
What is Combination Chemotherapy
300
Administer with a non-PVC bag and tubing with a micron filter. Hypersensitivity pre-medication regimen needed.
What is Taxanes (Paclitaxel and Docetaxel)
300
Camptothecins, Epipodophyllotoxins, Taxanes, and Vinca Alkaloids are all part of this classification.
What is Plant Alkaloids
300
Requirements for an approved chemotherapy gown.
What is disposable, lint-free, solid front, long sleeves with tight cuffs, and back closure.
400
Cancer Defined: The result of these 4 factors causing changes in a cells DNA.
What is Spontaneous transformation, environmental exposure, genetic alterations, and exposure to viruses.
400
A herbal/biotanical supplement known as a CYP3A4 Inducer that increases metabolism of a drug, which decreases the serum levels causing decreased efficacy of treatment drug.
What is St. Johns Wort
400
Classification: Examples include 'platin' drugs (cisplatin), and 'mide' drugs (ifosfamide, cyclophosphamide), and bendamustine. Can cause secondary malignancies.
What is Alkylating Agents
400
Classification: 'Mycin' drugs (bleomycin, mitomycin, adriamycin), colorful drugs. Cardiopulmonary toxicities.
What is Antitumor Antibiotics
400
4 types of chemotherapy dosing includes
What is Fixed Dosing, Mg/Kg weight based dosing, Mg/m2 BSA dosing, and AUC dosing
500
Method to prevent chemotherapy errors in regard to orders.
What is NO VERBAL ORDERS FOR CHEMOTHERAPY.
500
Blunting the immune response and obliteration of bone marrow in preparation for stem cell or bone marrow transplant.
What is Immunosuppression and Myeloablation.
500
Classification: Common side effects include myelosuppression, GI toxicities, and Cutaneous toxicities (hand-foot syndrome, nail changes), 'bine' drugs (cytarabine, capecitabine, decitabine)
What is Antimetabolites
500
Oral Chemotherapy for CML, melanoma, H&N cancers, metastatic ovarian cancer, and sickle cell anemia. Can cause renal failure and mucositis. Oral care is a must.
What is Hydroxyurea
500
Two immediate complications of chemotherapy administration
What is Hypersensitivity and Extravasation