Chlamydia

Intro to Chlamydia

100

Chlamydial inflection is the most frequently reported sexually transmitted infectious disease in the US. True or False

True! It is the most prevalent among women aged less than or equal to 24 years

200

What are the 3 types of chlamydia that can infected humans?

1. Chlamydia trachomatis 2. Chlamydia pneumonia 3. Chlamydia psittaci

300

Name 3 characteristics of chlamydia.

1. Non-motile 2. Gram-negative 3. Obligate intracellular pathogen

400

Which type of chlamydia is known to cause a respiratory infection in humans and is often spread from bird feces to humans?

Chlamydia psittaci

500

Why are chlamydia confined to intracellular growth?

Chlamydia lack the mechanism of producing ATP so they are dependent on their host.

Chlamydia's Developmental Cycle

100

What is the transmissible form of chlamydia?

Elementary body

200

What is type of cells do chlamydia like to infect?

Epithelial cells

300

Once the elementary bodies enter into the cell, they are reorganized into a larger __________________

Reticulate Body

400

How does chlamydia replicate itself?

Through binary fission

500

Once the membrane bound vacuole inside of the cytoplasm becomes filled with elementary bodies, it becomes what is a called an _______________________.

Intracellular cytoplasmic inclusion

Chlamydia trachomatis

100

What is a serovar?

A serovar is a variation within the species of bacteria. Each serovar has the same type of cell surface antigen

200

What is trachoma?

Trachoma is an ancient eye disease that is a chronic keratoconjunctivitis. It begins with acute inflammatory changes in the conjunctiva and cornea, but over years, this can progress to scarring and blindness. C. trachomatis serovars A, B, Ba and C are associated with clinical trachoma.

300

True or False. Approximately 10% of infected males and 20% of infected females are asymptomatic.

False. Approximately 50% of infected males and 80% of infected females are asymptomatic

400

Name 3 symptoms of C. trachomatis in symptomatic infected women.

1. Urethritis (dysuria, nonpurulent discharge, dysuria) 2. Cervicitis (discharge, endocervial secretions, edematous and hyperemic endocervical tissue) 3. Pelvic inflammatory disease

500

Which laboratory diagnosis test is the test of choice for diagnosing chlamydia?

Nucleic Acid Amplification Test (NAAT)

Grab Bag

100

True or False. Newborns may also acquire chlamydia infection during passage through an infected birth canal.

True. 30-50% of infants of infected mothers acquire the infection, often manifesting eye symptoms and issues with the respiratory tract such as pneumonia

200

Which serovar of C. trachomatis causes sexually transmitted diseases?

Serovar D-K

300

Which are the first line of pharmacologic treatment for chlamydial infection?

Tetracyclines and azithromycin

400

Which antibiotic is preferred for pregnant women infected with chlamydia?

Azithromycin

500

Why is chlamydial infection a risk factor for ectopic pregnancy?

Biological and epidemiological evidence suggest that chlamydia infection causes intense and persistent inflammation, injury, and scarring in the fallopian tube. Recent research has found that C. trachomatis and smoking leads to increased tubal PROKR2 (prokineticin receptor 2), which is a GPCR that predisposes the tubal microenvironment to ectopic implantation