Show:
Statins
Simvastatin
Omega 3 Fatty Acids/Zetia
Fibrates
Niacin
100
These are common SE of statin therapy
What is GI discomfort, myalgias, HA, flu like symptoms?
100
No new patients should be initiated on this dose of Simvastatin
What is 80mg?
100
Omega3 Fatty Acids have the most impact on this cholesterol value
What is decrease TG?
100
The important DDI with these medications
What is statins (increase incidence of myopathy)?
100
This medication affects which value of cholesterol the most
What is increase HDL?
200
These are the most clinically important SE of statin therapy
What is elevated LFTs, myopathy, and rhabdomyolysis?
200
The upper dosing limit of Simvastatin should only be used in patients who have been using it without any problems for this long
What is 1 year or greater?
200
The pros and cons of using OTC omega-3 fatty acids
What is cost (pro), calories (con) and amount (con)?
200
CIs for using this medication
What is severe renal or hepatic disease?
200
Common side effects of this medication
What is flushing and GI discomfort?
300
This is done if a patient has elevations<3xULN for transaminases
What is continue statin and recheck transaminase in 3 months (50% resolve on own)?
300
Dosing for Simvastatin should not exceed 10mg for these medications
What is amiodarone, verapamil, and diltiazem?
300
The type of Omega-3 that is most effective
What is EPA/DHA?
300
Common SE of using these medications
What is GI discomfort?
300
This is done to increase tolerance of this medication due to the side effect of flushing
What is give 325mg ASA 30 min before admin or 60 min before if EC, and take with food?
400
This is done if elevations >3xULN occur initially
What is continue statin and recheck level in a week?
400
Dosing for Simvastatin should not exceed 20mg for this medication
What is amlodipine?
400
Zetia therapy is initiated under these circumstances
What is last line therapy (after patient has failed other first line therapies with max doses or if not tolerated)
400
These are significant side effects of fibrates
What is heaptotoxicity, gallstones, and myopathy?
400
These are important CI for Niacin
What is severe gout, liver disease, and peptic ulcer
500
This is done if persistent levels of >3x ULN for transaminases occurs
What is decrease dose, d/c therapy or change to different statin and check for symptoms of liver toxicity?
500
Simvastatin has many drug interactions with these medications because of high first pass effect
What is azoles, gemfibrozil, erythromycin, clarithromycin, and HIV protease inhibitors (CYP3A4)?
500
Studies showed this about Zetia and its effect on LDL and CV occurence
What is reduction in LDL but NO reduction in CV events?
500
The ACCORD study showed this regarding diabetic patients being switched from statins to fibrates
What is no reduction in CV risk with fibrates?
500
The more significant side effects of this medication are?
What is hyperglycemia, hyperuricemia, and hepatotoxicity?