CIPD Studies

ProCHILDREN

100

Name the treatment arms (dose and frequency) for this trial

0.5g/kg

1.0g/kg

2.0g/kg

every 3 weeks 

200

This is the n in the ProCID trial

142

300

This percentage was the proportion of responders in the primary outcome 

79.7%

400

These are the circumstances in which patients received the rescue doses 

0.5-1g/kg: no improvement by week 6 OR worsening from week 3-18

500

These were the top 4 AEs in the ProCID trial

HA, Dermatitis, Pyrexia, Increased BP

ICE ICE BABY

100

This drug was studied in the ICE trial

Gammunex/Gammaked 

(Grifols)

200

This percentage of patients met the primary endpoint

54.7 %

300

List the top 3 AE for this study

HA, Pyrexia, HTN

400

This was the max mg of Prednisone allowed in this study

10mg/day 

500

Describe this trial design

LD with 2/kg then 1g/kg q 3 weeks or placebo

If INCAT worsened by at least 1 point @ anytime between day 16 or week 24 OR if INCAT did not change by week 6 pt crossed over to receive rescue treatment

After 24 week: randomized to get IVIG or placebo for 24 weeks @ dose of 1g/kg of IVIG or placebo over 1-2 days q 3 weeks

AMAZON PRIMA

100

This drug/company was the intervention in the PRIMA trial

Privigen/CSL

200

This trial had this number of week as its washout period

10 weeks

300

This was the percentage of patients who met the primary outcome

60.7%

400

These were the top AEs in the PRIMA study

HA, extremity pain, weakness, leukopenia, HTN

500

This was the response rate of patients who were NOT IVIG naive 

76.9 % :(

The PATH Less Traveled

100

This company and drug was the focus of the PATH trial

CSL/Hizentra 20%

200

These were the treatment  arms in the PATH trial

0.2g/kg

0.4g/kg

placebo

300

This was the primary endpoint in the PATH trial

Proportion of patients with CIDP relapse

400

What were the most common reactions in the PATH trial

infusion site reactions 

500

This was the author's conclusion in the PATH trial

Patients can be safely transitioned from IVIG to SCIG 

Call me Abraham

100

This is the storage requirement for Panzyga 10%

36 months frige-->12 months expired @ room temp 

200

This is the max infusion rate of Panzyga in CIPD

12mg/kg/min

300

These are the features in which CIPD is characterized by

Progressive, Symmetric, Proximal, Distal with weakness and sensory issues 

400

This was the max dose of Prednisolone (or equivalent) allowed in the ProCID trial

20mg/day

500

This is what the abbreviation for PANS means 

Pediatric Acute-onset Neuropsychiatric Syndrome