Cladribine

Clinical Trials

100

I provide immunomodulation through selective targeting of lymphocyte subtypes.

What is Cladribine

200

My primary endpoint was the rate of relapse at 96 weeks

What is Clarity Trial

300

I am the two doses of Cladribine given in the Clarity and Clarity Ext Studies....

What is 3.5 and 5.25mg/kg/body weight

400

I am the PRIMARY endpoint of the Clarity Trial

What is rate of relapse at 96 weeks

500

I am NOT inlcuded as a function measure of EDSS in the CLARITY trial

What is cognition....or what is changes in bowel or bladder function

Phase 3 Studies

100

I am a SECONDARY endpoint in the CLARITY study?

What is Proportion of patients who were relapse free and progression free

200

I am the most common adverse event after Cladribine treatment in CLARITY trial

What is HEADACHE

300

I am an adverse effect.........but also vital as I am part of the mechanism of action of Cladribine....

What is lymphocytopenia

400

I am a latent virus that was activated in 20 patients treated with Cladribine in the CLARITY study

What is Herpes Zoster

500

I am the THREE types of neoplasms diagnosed in patients Cladribine in the Clarity trial (3.25mg/kg)

What is melenoma, ovarian, and pancreatic carcinoma

MOA

100

I had an incidence of zero in the placebo group

What is the Clarity Trial

200

I am a purine nucleoside required for DNA synthesis

What is deoxyadenosine

300

I am a type of cell that has a high kinase to phosphatase ratio compared to other cells

What is a lymphocyte?

400

Due to selectivity, i have a transient effect on this cell

What is NK cells, neurtiphs, platelets

500

This anti-inflammatory cytokine is increased after treatment with Cladribine....hint I am an Interleukin....

What is IL4, IL5, IL10

Pharma

100

I am a company based in Damstad German

What is Merck

200

I decrease CD19 + cells to negligible levels by 2 weeks of treatment

What is Ocreluzimab

300

Treatment with me leads to persistant reduction of peripheral lymphocyte counts and I am taken dayly at a dose of 0.5mg

What is Fingolimod

400

I am a drug that fills a need for a highly effective MS therapy without the risks associated with continuous immunosupression

What is Cladribine

500

I am a therapy type that is different from chronic immunosupression and immunomodulation

What is Immune Reset Therapy

WILD CARD

100

I am a song is most commonly sung to celebrate someone getting a year older?

What is Happy Birthday

200

I am the historical region of Greece includes the capital, Athens?

What is Attica

300

I am the country in which Posh and Becks married

What is Ireland

400

I am a large animal, and the only creature thought to produce its own sun tan lotion from its natural secretions

What is a Hippopotamus

500

I am a song from 'Joseph and his technicolour dreamcoat' that gave Jason Donovan a No 1 UK hit in 1991

What is Any dream will do