Microbiology
Presentation
Diagnosis
Treatment
Prevention
100

Gram stain and metabolism

What is Gram-positive anaerobic bacillus?

100

Most common symptom

What is watery diarrhea (>3 loose stools in 24h)?

100

Initial diagnostic test

What is GDH antigen and toxin A/B in stool? 

100

First line treatment for nonsevere CDI based on 2021 IDSA guidelines

What is fidaxomicin?

100

Risk factors for recurrent CDI

What is age > 65, severe underlying medical disorder, serum creatinine ≥ 1.2 mg/dL, lack of antibody-mediated immune response to toxin B? 

200
Mechanism of pathogenicity
What is exotoxin (A and B) production? 
200

Three main clinical presentations

What is non-severe disease, severe disease and fulminant colitis? 
200

GDH antigen positive and toxin A/B negative: next step

What is toxin B gene PCR (NAAT) if meeting criteria for disease?

200

First line treatment for recurrent CDI (first recurrence)

What is fidaxomicin? 

200

Three antibiotics (or classes) often associated with CDI

What is fluoroquinolones, clindamycin, cephalosporins (2nd generation and above), carbapenems, penicillin?

300

Mechanism of infection

What is spore ingestion?

300

Definition of severe disease

What is WBC >15000 cells/µL or serum creatinine >1.5 mg/dL? 

300

Two tests that when positive may lead to overdiagnosis of colonization

What is GDH and toxin B gene PCR (NAAT)?

300

First line treatment for severe CDI

What is fidaxomicin?
300

Color of container lid for appropriate wipes to use for CDI prevention (sporicidal)

What is orange?

400

Bacterial forms

What is spore and vegetative? 

400

Definition of fulminant colitis

What is hypovolemic shock, ileus or megacolon/bowel perforation? 

400

Two less common laboratory diagnostic tests for CDI

What is selective anaerobic culture and cell culture cytotoxicity assay? 

400

First line treatment for fulminant colitis (dose and frequency)

What is oral vancomycin 500 mg q6h and IV metronidazole 500 mg q8h for 

400

Target of Bezlotoxumab

What is toxin B?

500

Hypervirulent strain

What is NAP1/B1/027?

500

Definition of recurrent disease

What is reappearance of symptoms within 2-8 weeks after treatment has been stopped?

500

Unhelpful stool test for CDI

What is fecal leukocyte testing?

500

Most appropriate timing of FMT

What is after third recurrence? 

500

Name of first FDA-approved fecal microbiota product to prevent recurrent CDI

What is Rebyota?