Coagulation Cascade

A

100

Which part of hemostasis involves the coagulation cascade?

Secondary Hemostasis

200

Factors II, VII, IX, X

What factors are Vitamin K dependent?

300

If blood is placed into an empty untreated test tube, what pathway will it primarily clot through?

Intrinsic

B

100

Factors XII, XI, IX, and VIII

What are the factors involved in the intrinsic pathway?

200

TF-VIIa complex with calcium

What activates Factor X via the extrinsic pathway?

300

What factor is VWF bound to?

Factor VIII

C

100

Factor III and VII

What are the factors involved in the extrinsic pathway?

200

Exposed subendothelial collagen/Negatively charged surfaces, Kallikrein, and HMWK (high molecular weight kininogen)

What 3 things directly activate Hageman Factor?

300

What factor has the shortest half-life?

Factor VII

D

100

Factors XIII, X, V, II, and I

What factors are involved in the common pathway?

200

What reactions is thrombin involved in?

XIII to XIIIa

VIII to VIIa

V to Va

I to Ia

300

Va, Xa, Phospholipid, and Calcium

What makes up the prothrombinase complex?

E

100

Factor IV

What is calcium?

200

Fibrin Stabilizing Factor

What is another name for Factor XIII?

300

What steps require calcium?

TF-VII activity

IX, X (int and ext), and II activation