Factor Groups
What factors are part of the Contact Group?
HMWK, PK, XI and XII
What is the name of Factor II? What is its name when it is activated?
II = Prothrombin, IIa = Thrombin
What factors are in the Common Pathway?
Factors I, II, V, and X
What does the anti-Xa assay monitor?
Low molecular weight Heparin and unfractionated Heparin
What lab assay will monitor the Intrinsic Pathway?
aPTT
What factors are part of the Prothrombin Group?
II, VII, IX, and X
What is the name of Factor IX?
Christmas factor
What factors are in the Intrinsic Pathway?
Factors HMWK, PK, VIII, IX, XI, and XII
Which assay has a shorter "normal range":
PT or PTT?
PT
What lab assay will measure the Extrinsic Pathway?
PT
What factors are part of the Fibrinogen Group?
I, V, VIII, and XIII
What is the name of Factor X?
Stuart factor
What factors are in the Extrinsic Pathway?
VII, TF (III), Calcium Ions
What conditions can the D-Dimer assay help to diagnose?
DIC and DVT or PE
A prolonged PT can indicate a deficiency of what factors?
Factors VII, I, II, V, or X
(Factors in the Extrinsic and Common Pathway)
What factors are Vitamin K dependent?
The Prothrombin Group: II, VII, IX, and X
What is the name of Factor V?
Proaccelerin
How is the Intrinsic Pathway activated?
Contact activation with collagen and platelets
What type of specimen is used to perform MOST coagulation testing?
The plasma from a sodium citrate tube.
A prolonged aPTT can indicate a deficiency of what factors?
Factors VIII, IX, XI, XII, I, II, V, or X
(Factors in the Intrinsic and Common Pathway)
What factors are used up in clot formation?
The Fibrinogen Group: I, V, VIII, and XIII
Which factor produces the stabilized fibrin clot when it is activated?
Factor XIII (fibrin-stabilizing factor)
How is the Extrinsic Pathway activated?
Vessel injury
Why is an "INR" value given with a PT result?
The INR is a calculation that corrects for the variability in PT results caused by the variable sensitivities (ISI) of the reagents. It is used to standardize the difference in sensitivity of reagents.
Why would you perform a mixing study?
When you have a prolonged aPTT and need to distinguish between a coagulation factor deficiency and a factor inhibitor.