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Principles of Hemostasis
Testing
Platelets
Anticoagulants and Therapeutic agents
Platelets II
100
A deficiency of vitamin C (scurvy) acts as a cofactor for the synthesis of the this.
What is collagen
100
In platelet aggregation studies, the aggregating agent inducing a biphasic aggregation curve. The second phase is caused by this.
What is release of endogenous ADP.
100
The function of thromboxane A2
What is stimulate platelet aggregation
100
The medicinal property of aspirin and Plavix.
What is antiplatelet medication
100
The shape of a normal histogram showing platelet size distrubution.
What is right-skewed single peak
200
The number of platelets an average megakaryocyte generates.
What is 2000-4000
200
3 aggregating agents that cause a biphasic curve when used in optimal concentration.
What are epinephrine, ADP, and thrombin
200
The most potent inhibitor of platelet aggregation and released by endothelial cells
What is prostacyclin (PGI2)
200
The anticoagulant required for routine coagulation.
What is sodium citrate.
200
The maturation stages of a platelet.
What is megakaryoblast, promegakaryocyte, megakaryocyte, platelets
300
Platelets interacting with and binding to other platelets.
What is aggregation
300
The only aggregating agent that has a lag phase indicating the lapse during platelet release of ADP.
What is collagen.
300
Released in platelet secretions, epinephrine and ristocetin function.
What is potent stimulators of platelet aggregation
300
The test used to evaluate coumadin therapy
What is the protime
300
The three stages of platelet activity in coagulation
What are adhesion, aggregation, and secretion.
400
The site where most factors are synthesized.
What is the liver
400
The operating principle of a platelet aggregometer
What is change of optical density as platelets aggregate, the optical density decreases.
400
The reference value for MPV
What is 8-10 fL
400
The test used to evaluate heparin therapy
What is APTT
400
Two clinical signs that platelet function is abnormal.
What is bruising, petechiae, ecchymoses, purpura, epistaxis, mucosal bleeding, and gingival bleeding.
500
Two sources of von Willebrand factor.
What are endothelial cells and megakaryocytes.
500
The preferred type of microscopy for manual platelet counts.
What is phase contrast.
500
The platelet parameter that reflects variation in platelet size.
What is PDW
500
The anticoagulant most likely to cause thrmbocytopenia.
What is unfractionated heparin (HIT)
500
Needed for platelets to adhere to collagen in damaged vessels.
What is von willebrand factor.