Rule of 3's
Classical, Alternative, Lectin
Name the sub-unit of C1 that binds directly to pathogen surfaces or indirectly to antibody bound to pathogens
C1q
The the pathway that utilizes antibodies to initiate complement
Classical Pathway
Also known as the lab rat of bacteria, this microbe is recognized via PAMPs by the lectin pathway
What is E-coli?
The 3 of us work to tip the first domino
What are c1q, c1r, c1s?
Name the sub-unit of C1 that cleaves C4 and C2
C1s
The order of activation for the classical pathway
C1, C2, C4, C3, C5, C6, C7, C8, C9
Natural antibodies (produced in absence of infection) are good at clearing this common bacterial infection that causes cough, fever and shallow breathing.
What is pneumonia?
All roads lead to this 3-letter word
What is the MAC (membrane attack complex)?
Fill in the blank: C2aC4bC3b cleaves this protein, generating the protein sub-unit "__b" that then binds C6, C7, C8, and C9 to effectuate MAC
C5
When IgM binds a pathogen, it forms this conformation, allowing C3q activation
Staple Conformation
C3a and C5a induce a circulatory collapse, producing shock seen in this IgE mediated response toward allergens.
What is anaphylactic shock?
These fragments induce histamine release via mast cell activation
What are C3a, C4a, and C5a?
Name the classical pathway and lectin pathway C3 convertase
C4b2a
It is involved in the classical pathway, but not in the other two complement pathways
Antibody
Properdin deficient patients are susceptible to this common infection that causes stiff neck, coma and possibly death.