PRIORITY DECISION MAKING
CASE PROGRESSION
PHARM + PATHO INTEGRATION
COMPLICATION CHAINS
“WHAT WOULD YOU DO NEXT?”
100

A patient with a history of lung cancer presents with confusion, Na⁺ 118, and low urine output. What is the priority nursing action?


Initiate fluid restriction and monitor for SIADH-related hyponatremia.


100

A stroke patient initially improves, then suddenly develops headache and vomiting after thrombolytic therapy. What is occurring?

Intracranial hemorrhage.

100

A patient receiving Alteplase begins bleeding from IV sites. What is the underlying mechanism?

Systemic fibrinolysis breaking down clots.

100

Lung cancer → SIADH → hyponatremia → what neurologic complication?

Seizures.

100

A seizure patient stops seizing but is unresponsive. What is the next priority?

Assess airway and breathing.

200

A patient with pancreatitis becomes hypotensive (BP 86/50), tachycardic, and has decreased urine output. What is the FIRST intervention?


Initiate aggressive IV fluid resuscitation (Lactated Ringers).

200

A spinal cord injury patient develops sudden hypertension, bradycardia, and severe headache during catheterization. What is happening?

Autonomic dysreflexia.

200

A patient with ICP elevation is given Mannitol. Why must kidney function be monitored?

Risk of renal failure from osmotic diuresis.

200

SCI → bladder distention → autonomic dysreflexia → what life-threatening risk?


Stroke from severe hypertension.

200

A patient receiving chemo develops a fever. What is the FIRST action?

Notify provider and initiate neutropenic protocol.

300

A TBI patient becomes restless with ICP rising from 15 to 24 mm Hg. What is the priority action?

Reduce stimulation and ensure proper positioning (HOB elevated, head midline).

300

A meningitis patient becomes increasingly lethargic with unequal pupils. What complication is developing?

Increased ICP with possible brain herniation.

300

A chemotherapy patient receiving Vincristine develops numbness in hands and feet. Why?

Neurotoxicity causing peripheral neuropathy.

300

Pancreatitis → fluid shifts → what type of shock?

Hypovolemic shock.

300

A stroke patient’s BP is 210/110 prior to thrombolytics. What is the next step?


Administer Labetalol to lower BP safely.

400

A leukemia patient develops a fever of 101°F with ANC <500. What is the priority?


Treat as neutropenic fever — initiate antibiotics immediately.

400

A pancreatitis patient suddenly has decreased pain but worsening vitals and confusion. What does this indicate?

Pancreatic necrosis.

400

A patient with cirrhosis on Spironolactone develops hyperkalemia. Why?

Potassium retention due to aldosterone blockade.

400

Leukemia → neutropenia → what complication?

Severe infection/sepsis.

400

A patient with ascites has increasing abdominal pressure and dyspnea. What is the next step?


Prepare for paracentesis.

500

A patient with cirrhosis becomes acutely confused with asterixis. What is the priority intervention?

Administer Lactulose to reduce ammonia levels.

500

A liver failure patient becomes progressively drowsy and difficult to arouse. What stage are they progressing toward?

Hepatic coma.

500

A patient with seizures receives Lorazepam followed by Phenytoin. Why both?

Lorazepam stops acute seizure; phenytoin prevents recurrence.

500

Cirrhosis → portal hypertension → what life-threatening bleeding risk?

Esophageal varices rupture.

500

A TBI patient’s ICP spikes suddenly. What is the FIRST immediate intervention?


Reposition head (midline, elevate HOB) to improve venous drainage.