This enzyme acetylates the E-amino group within the R side chain of the lysine residues to neutralize the positive charge of lysine. Loosens the DNA
What is
Histone Acetyltransferase (HAT)
100
This eukaryotic DNA polymerase is involved in DNA repair via 3' --> 5' exonuclease activity
What is
DNA Polymerase Beta
100
This enzyme binds to the MINOR GROOVE of the TATA box to initiate the PIC, facilitating strand usage, direction and location
What is
TATA Binding Protein (TBP)
100
This transcription factor binds to the initiator tRNA-Met and delivers it to the P site of the ribosomal subunit
What is
eIF2
100
This chaperone protein forms and shuffles disulfide bonds
What is
Protein Disulfide Isomerase (PDI)
200
This enzyme removes acetyl groups from DNA to prevent acetylation, Tightens DNA.
What is
Histone Deacetylase (HDAC)
200
This prokaryotic DNA polymerase is the main processive enzyme in the replication of prokaryotic DNA
What is
DNA Polymerase III
200
This enzyme has helicase properties, phosphorylates the CTD of RNA Pol II and is involved in the Nucleotide Excision Repair pathway
What is
TFIIH
200
This transcription factor binds to the 40S ribosomal subunit, preventing it from combining with the 60S ribosomal subunit until the translation process is set to begin
What is
eIF3
200
This specific chain of a type of poison is commonly found in children's classrooms (how effing stupid is that?) targets rRNA for degradation, preventing further protein translation
What is
Alpha Chain of Ricin
300
This enzyme methylates DNA, prevents Acetylation. Tightens DNA
What is
Histone Methyltransferase (HMT)
300
These enzymes are the main processive DNA polymerases in eukaryotes
What are
DNA Polymerase Delta and DNA Polymerase Epsilon
300
This enzyme is responsible for phosphorylation of the CTD of RNA Pol II after being stimulated by Cyclin T [in response to HIV Tat protein]
What is
CDK9
300
This transcription factor scans the mRNA for the start codon
What is
eIF4B
300
The longer form of this protein is commonly implicated in Alzheimer's Disease
What is
Amyloid Precursor Protein (APP) -- specifically AB42
400
This enzyme complex mediates Histone Acetyltransferase (HAT) function, regulating decondensation of DNA
What is
SWI/SNF Complex
400
This enzyme recognizes DNA damage in the Mismatch Repair Pathway
What is
MLH1 (and MLH2)
400
This earthly toxin binds to RNA Pol II away from the active site and prevents transcription from occurring, leading to an untimely death
What is
Alpha-Amanitin
400
This antibiotic inhibits peptidyl transferase function
What is
Chloramphenicol
400
2 specific homozygous allele pairs of this protein can lead to very different outcomes in Late Onset Alzheimer's Disease
What is
Apolipoprotein E
(E2/E2 = Protective; E4/E4 = Harmful)
500
This enzyme represses histone acetyltransferases and facilitates histone deacetylases
What is
Histone 1 (H1)
500
These proteins recognize DNA damage in the Nucleotide Excision Repair pathway
What are
Rad23B and XP-C
500
This antibiotic inhibits RNA transcription by binding to RNA Pol II
What is
Rifamycin
500
With this unexpected stop, all downstream translation ceases to occur
What is
Nonsense Mutation
500
This diseased form of the alpha-synuclein protein has been implicated in Parkinson's Disease