PI
What is the half-life of Tafamadis?
what is 49 hours
Who is the lead author for the ATTR-ACT trial?
who is Matt Maurer
ASNC stands for?
American Society of Nuclear Cardiology
His nickname was Broadway Joe?
who is Joe Namath
The Witteles Paper appeared in what Journal?
JACC Heart Failure
Tafamadis peak concentrations occurred?
what is within 4 hours following dosing
How many Patients were randomly assigned in the trial?
what is 441
For PYP testing ASNC practice points indicate parameters for Patient Preparation are ?
What is no specific preparation, no fasting required
who won the first Super Bowl Game?
Who are the Green Bay Packers
ATTR-CM is a _______ _______, _______ disease that is often _______ and _______
what is Life-threatening, Progressive, underdiagnosed, misdiagnosed
Stabilizing the tetramer and slowing dissociation into monomers is know as?
what is the Rate-limiting step in the amyloidogenic process
What was the P value for FS method in the primary analysis?
what is >0.001
According to ASNC time between injection and acquisition?
what is Recommended: 1 hr SPECT and Planar
Optional:3 hr SPECT or Planar
Who has the second most NBA Championships?
Who are the LA Lakers
The Witteles paper sites what % of adult autopsy patients 80 years or older had significant TTR amyloid deposits?
What is 25%
The highest dose of Tafamadis given to healthy volunteers in a clinical trial?
What is 480mg as a single dose
what was the P value for FS method in Class III patients?
what is 0.78
How is the H/CL ratio calculated?
what is dividing the ROI over the heart mean CT's to the contralateral chest ROI mean CT's
Whose Nickname was the Georgia Peach?
Who is Ty Cobb
In a survey of ATTR-CM patients what % of respondents reported visiting 5 different physicians before receiving a correct diagnosis?
what is 17%
What is the molecular weight of tafamadis?
what is 503.33g/mol
Exploratory endpoints included a smaller increase in the ________ Level among patients receiving tafamadis?
what is NT-proBNP
what are AL Amyloid or early ATTR cardiac amyloid
what was the name of the Immortalized Running Play called by the KC Chiefs in Super Bowl IV?
what is 65 Toss Power Trap
_______ ________ levels are often persistently elevated in ATTR-CM?
what are Serum Troponin