Fun Facts
Abbreviated IGI, this institute offers the world's premiere journal club.
What is the Innovative Genomics Institute?
This is easily the most famous Cas protein.
What is Cas9?
Aaron Pomerantz spends his days editing these organisms, wondering how their DNA controls their ornate wing patterns.
What are butterflies?
This disgraced scientist edited the first "CRISPR babies."
Who is He Jiankui?
Many online tools exist to help would-be genome editors design these molecules, which direct Cas effectors to genomic target sites.
What are guide RNAs?
What is sickle cell disease?
Biggiephages encode this protein, whose discoverers eschewed traditional naming conventions.
What is CasPhi?
Banfield lab scientists recently developed a method to engineer microbes within diverse microbial communities, and rely on this sequencing approach to detect their edits.
What is metagenomic sequencing?
UC Berkeley continues to battle this organization over the IP rights to the CRISPR-Cas9 system.
What is the Broad Institute?
A double-strand break can trigger repair through two common pathways, HDR and this "error-prone" option.
What is NHEJ?
During her first research experience, Jennifer Doudna studied how the fungus Phytophthora palmivora infects this tropical fruit, popular in her home state of Hawaii.
What is papaya?
This Cas protein targets RNA and can be used in diagnostics.
What is Cas13?
Golden rice is engineered to produce this precursor of vitamin A.
What is beta-carotene?
This wooly scientist is trying to edit elephant cells to "resurrect" wooly mammoths.
Who is George Church?
To make double-strand breaks, Cas9 uses a RuvC domain and this nuclease domain, named for conserved amino acids in its active site.
What is an HNH domain?
As "Walk Like an Egyptian" topped the charts, the first CRISPR array was discovered during this year.
What is 1987?
Involved in acquisition, this protein is part of every functioning CRISPR system.
What is Cas1?
In 2019, scientists edited snails to change whether their shells twist to the left or to the right, uncovering the genetic basis of this geometric property, which gets its name from the Ancient Greek word for hand.
What is chirality?
This self-proclaimed "biohacker" publicly injected himself with what he claimed were genome editing reagents in 2017.
Who is Josiah Zayner?
The Cas9 protein from Streptococcus pyogenes recognizes this three-letter PAM sequence.
She is Megan’s all-time favorite CRISPR scientist.
Who is Makarova?
Named after a mountain range, this multi-subunit effector complex recruits a separate nuclease-helicase to cleave its DNA targets.
What is Cascade?
When this gene, which controls muscle growth is naturally mutated or knocked out with CRISPR, beagles, cattle, and other lab animals get swoll.
What is myostatin?
CEO of Caribou Biosciences, this Doudna lab alum spent her time in grad school studying crRNA-processing enzymes.
Who is Rachel Haurwitz?
Base editing uses a Cas9 protein fused to this enzyme, which comes in varieties that act on cytosine or adenine.
What is deaminase?