CD Induction
This is a TNF-alpha inhibitor approved for CD induction in moderate to severe disease activity.
What is: (Acceptable answers)
adalimumab
infliximab
certolizumab
This is the only non-biologic with strong recommendations for maintenance therapy in moderate-severe Crohn's Disease.
(NOT STEROIDS)
What is RINVOQ (upabacitinib)?
This formulation [method of delivery] of mesalamine used as monotherapy is only recommended in patients with mildly active ulcerative proctitis or distal colitis
What is the rectal formulation of mesalamine?
This is the only JAK inhibitor approved for moderate to severe disease in Crohn's Disease.
What is upadacitinib? (RINVOQ)?
This biologic is only indicated for CD and is preferred in pregnancy and breastfeeding because it lacks the Fc fragment of IgG, which is what binds to the neonatal Fc receptor and is transported to the placenta.
What is certolizumab-pegol?
This is an IL-12/IL23 inhibitor approved for CD induction in moderate to severe disease activity.
What is ustekinumab? (STELARA)
Selarsdi (ustekinumab-aekn)
OTULFI (ustekinumab-aauz)
WEZLANA (ustekinumab-auub)
YESINTEK (ustekinumab-kfce)
SteQeyma (ustekinumab-stba)
Pyzchiva (ustekinumab-ttwe) (+ other generics)
This is a humanized monoclonal IgG1 antibody that binds to p19 subunit of IL23.
What is risankizumab (SKYRIZI)?
This TNF is indicated for moderate-severe ulcerative colitis induction and is only available by the brand name SIMPONI
What is golimumab?
This therapy should be avoided in those that have deficiency in either TPMT or NUD15.
What is azathioprine?
A biologic that two RCTs assessed the efficacy and safety as maintenance therapy [400 mg every 4 weeks] in patients with moderate-to-severe CD
Trials: PRECISE I & PRECISE II
What is certolizumab-pegol?
This is the naming suffix used for HUMANIZED monoclonal antibodies.
What is -ZUMAB
This monoclonal IgG1 antibody acts by blocking the α4β7 integrin, resulting in disruption of lymphocyte trafficking and anti-inflammatory activity.
What is Vedolizumab (Entyvio®)?
This is the JAKi approved for both induction and maintenance of ulcerative colitis.
What is tofacitinib? (XELJANZ)
This TNF can be recommended in combination with an immunomodulator for the CD Maintenance or remission therapy in individuals that are at risk of treatment failure such as those that failed a different TNF, or if there is concern for the development of immunogenicity. Most other TNF inhibitors do not exibit additional benefit for combination therapy, but this TNF has evidence of benefit in the populations listed.
What is infliximab?
In regards to biologics this type of mab has lower immunogenicity than murine but more than human.
What are humanized [mAB]?
This class of medications is considered first line for ulcerative colitis but is no longer recommended for induction therapy in Crohn's Disease.
What is 5-ASA?
Other acceptable answers:
Mesalamine
Sulfasalazine
Olsalazine
Balsalazide
Guidelines strongly recommend this biologic for moderate-to-severe Crohn disease patients who failed previous treatment with corticosteroids, thiopurines, methotrexate, or TNF-blockers or in those persons who have had no prior exposure to TNF-blockers. Additionally several biologics are now available.
What is ustekinumab?
This product has activity all the way to the ilieum.
What is Asacol?
This is the steroid recommended for induction of mild-moderate CD (limited to the ileum and/or ascending colon). It provides local action rather than systemic in the formulation formulated for CD. It does NOT have a role as maintenance therapy.
What is budesonide?
For patients with Peripheral Spondyloarthropathy (an extra-intestinal manifestation in Crohn's Disease) either of these 3 treatment options are strongly recommended. (Highest level of evidence)
What are:
infliximab
adalimumab
certolizumab
Serum antibody to _________virus must be negative in order to initiate _________ therapy.
What is the John Cunningham (JC) virus?
What is natalizumab (TSABRI) therapy?
This is a human IgG1 monoclonal antibody that selectively binds to the p19 subunit of interleukin 23 (IL-23) cytokine, inhibiting its interaction with the IL-23 receptor.
What is guselkumab (TREMFYA)?
This 5-ASA has activity all the way to the jejunum
What is Pentasa?
Although, not preferred, this type of therapy can be used for induction therapy in patients with active moderate to severe CD. They are effective but associated with significant morbidity and mortality.
What are systemic corticosteroids?
This biologic was approved for moderate to severe Crohn disease in January 2025. It is a monoclonal antibody that targets the p19 subunit of interleukin-23. It is now approved in the United States for treating moderate to severe Crohn disease.
What is Mirkizumab (OMVOH)?