Neurons
Cochlear Nucleus
Superior Olive
Lateral Lemniscus + Inferior Colliculus
Medical Geniculate Body + Auditory Cortex
100
A brief electrical event typically generated in the axon that signals the neuron as 'active’. Includes a rapid POSITIVE change in voltage across a cell membrane.
An ACTION POTENTIAL travels the length of the axon and causes release of neurotransmitter into the synapse.
100
What part of the brainstem is the Cochlear Nucleus in?
Medulla
100
The SOC is involved in sound localization by comparing timing and intensity differences of sounds received from each ear. Describe Interaural Time Differences (ITDs).
ITDs refer to the difference in the time it takes for a sound to reach each ear. When a sound source is closer to one ear, it arrives at that ear slightly earlier than it does at the other ear.
100
The Lateral Lemniscus + Inferior Colliculus generate one wave together on the ABR. What wave is that?
Wave V (I will ask you about all the waves on your exam!)
100
True or False: the thalamus (where the MGB is located) ONLY processing auditory information.
The thalamus consists of multiple nuclei, each with specific functions and connections to different parts of the brain. Different nuclei/divisions process different sensory processes including vision, memory, and emotions.
200
A(n) __________ is a receiving part of the neuron.
A(n) ________ transmitting part of the neuron.
DENDRITES and AXONS
200
What are the two main divisions of the cochlear nucleus?
Which is both bigger and has two sub-divisions within it?
- Ventral cochlear nucleus (VCN) (Further divided into the AVCN and PVCN)
- Dorsal cochlear nucleus (DCN)
200
What part of the brainstem is the Superior Olive in?
Pons
200
What are the two key nuclei/divisions of the lateral lemniscus?
- Ventral Nucleus of the LL (VNLL)
- Dorsal Nucleus of the LL (DNLL)
200
___________ _______________ are pathways that connect the auditory cortex back to the MGB in the thalamus and vice vesa.
Corticothalamic Projections
300
Chemical messengers that carry signals between nerve cells - from the presynapse to the postsynapse
Neurotransmitters
300
The precise area where auditory nerve fibers (coming from the cochlea) enter the cochlear nucleus in the brainstem.
ROOT ENTRY ZONE
300
What are the three nuclei of the superior olive?
-Lateral Superior Olive (LSO)
-Medial Superior Olive (MSO)
- Medial Nucleus of the Trapezoid Body (MNTB)
300
What part of the brainstem is the Inferior Colliculus in?
Midbrain
300
Most of the auditory system, starting at the basilar membrane, is tonotopically organized. What part of the auditory cortex does NOT have robust tonotopicity?
The Secondary Auditory Cortex (A2) and Auditory Association Areas
400
A post-stimulus time histogram is a graphical representation of how often a neuron fires over time in response to a stimulus. It's used to understand how neural firing patterns change after a stimulus begins.
What is plotted on the x-axis and the y-axis?
x-axis: TIME (usually MS)
y-axis: SPIKES PER SECOND
400
The three main fiber pathways through which auditory information travels through most of the brainstem.
- Dorsal Acoustic Stria
- Intermediate Acoustic Stria
- Ventral Acoustic Stria
400
There are three possible firing patterns/events that the SOC can recieve a combination of from ipsi and contra input from the cochlear nucleus. What are those three firing patterns?
- Excitatory (E)
- Inhibitory (I)
- Unaffected (O)
400
True or False: the startle reflex is a conscious process
FALSE.
The startle reflex is an automatic, rapid response to sudden, loud, or unexpected sounds. It involves a series of neural and motor pathways that allow the body to react quickly to potential threats, bypassing conscious processing for a faster response.
400
We learned about 5 different Auditory Association Areas. Name some.
- Insular Cortex
- Broca’s Area
- Wernicke’s Area
- Planum Temporale
- Angular Gyrus
500
There are 5 types of PSTHs you need to know about for this class. Lets name some!
(For your exam, you'll also need to know what cell-type they're generated by.)
1. Primary-like
2. Chopper
3. Primary-like with notch
4. Onset
5. Pauser
500
Fibers from the Cochlear Nucleus travel to the Superior Olivary Complex next on the ascending pathway. What is unique about the paths they take that hasn't happened in the auditory system until now?
Fibers from the Cochlear Nucleus are going to travel to both the IPSILETERAL and CONTRALATERAL Superior Olive.
500
What combination of Excitatory (E) / Inhibitory (I) / Unaffected (O) (e.g. EE, EI, EO, II, etc.)
II (Inhibatory-Inhibatory) is least likely likely to generate an action potential because the SOC will beas negaitve as possible, and we need a positive voltage to fire an action potential.
500
The Inferior Colliculus is the “main point of convergence” in the brainstem. What does this mean?
The central nucleus of the IC receives input from the LL, but also the rest of the lower central auditory system (including the CN, SOC and LL). Everything meets here before heading to the MGB.
500
The Auditory Cortex is the last structure on the ASCENDING or DESCENDING auditory pathway?
ASCENDING (Outer Ear -- > Cortex)