4 letter "Words"
lost travelers might seek these letters for direction
NESW
Pc gamers comfortable with a keyboard commonly use these letter key for movement
WASD
Scrabble players aiming to score big may try to play these four highest valued letter on bonus spaces
QJZX
AKQJ
Your biological make-up can be expressed using these four letters. Though it may take time to get all the sequences written down.
AGTC