1
Generic name for Daraprim
What is pyrimethamine?
Pregnancy Category of Daraprim
What is Pregnancy Category C?
Daraprim is available in bottles of _____ count and _______ count.
What is 30 and 100?
If signs of folate deficiency develop, pyrimethaminie should be __________.
What is discontinued?
Daraprim is highly selective against ____________.
What is toxoplasma gondii?
Half life of Daraprim
What is 96 hours?
Pyrimethamine is a folic acid ___________
What is antagonist?
Patients should be warned if ______ and _______ occur, it may be minimized by taking Daraprim with meals.
What is anorexia and vomiting?
__________ _________ occasionally severe, can occur particularly when Daraprim is administered with a sulfonamide.
What is hypersensitivity reactions?
TRUE OR FALSE?
Daraprim in 2 humans indicate that it may be carcinogenic.
What is TRUE?
2 drugs that should be co-administered with Daraprim?
What is Leucovorin (folinic acid) and Sulfonamide
The indication for Daraprim
What is: Daraprim is indicated for the treatment of toxoplasmosis when used conjointly with a sulfonamide, since synergism exists with the combination?
Clinical studies of Daraprim ____ ____ ____ sufficient number of patients aged 65 and over to determine whether they respond differently from younger subjects.
What is "did not include?"
DAILY DOUBLE!!!!
TRUE OR FALSE:
Daraprim is NOT excreted in breast milk.
What is FALSE?
In patients receiving high dosage, __________ blood counts, including platelet counts should be performed.
What is semiweekly?
Available dosage of Daraprim
What is 25 mg scored tablets?
________ monitoring of peripheral blood counts is recommended for up to several weeks after the overdose until normal hematologic values are restored.
What is daily?
DAILY DOUBLE!!!!
When was the PI for Daraprim updated?
What is April 2017?
The adult starting dose of Daraprim
What is: 50-75 mg daily, with 1-4 g daily of a sulfonamide (along with folinic acid.) Our PI does not give a recommended dose for folinic acid; we will discuss with CDC/NIH guidelines.
Daraprim should be used in pregnancy only if________________.
What is: if the potential benefit outweighs the potential risk to the fetus?
Name 2 contraindications with Daraprim
What is :
1. Known hypersensitivity to Pyrimethamine
2. Pts with hx of megaloblastic anemia due to folate deficiency
2 potential hematologic effects that can occur with Daraprim?
What are: Megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, neutropenia?
Daraprim should be used with caution in patients with impaired _____ or _______ function of in those with folate __________.
What is renal or hepatic, and deficiency?
In the event of overdosage, ______ _______ is recommended and ______ _______ may be used to control convulsions. ______ ______ should be administered within 2 hours to counteract the effects on the hematopoietic system.
What is gastric lavage, parenteral diazepam, and folinic acid?
Daraprim is an _____________ compound.
What is antiparasitic?