not ILD anymore
DPLD associated with "sandblasting" workers and eggshell calcification of hilar lymph nodes.
Silicosis
Diffuse thin-walled cysts in a reproductive-age female non-smoker
Lymphangioleiomyomatosis (LAM)
occurs in > 55% of women with TSC mutations (55% of women with TSC2 mutation, 0% in TSC1 mutation)
lymphangioleiomyomas and chylous collections occur less frequently in TSC-LAM (10%) compared to sporadic LAM (30-40%)
Management of a solitary pulmonary nodule >8mm with high probability of malignancy
Biopsy or Resection (possibly PET/CT)
Triple Negative breast cancer phenotype is most commonly associated with this genetic mutation.
BRCA1
Smoking cessation aid that may cause vivid dreams or neuropsychiatric side effects.
Varenicline
Histopathologic finding required for the diagnosis of Idiopathic Pulmonary Fibrosis (IPF).
Usual Interstitial Pneumonia
Pneumothorax occurring within 72 hours of onset of menses.
Catamenial Pneumothorax
(Accept Thoracic/pulmonary Endometriosis)
The most common paraneoplastic syndrome associated with Small Cell Lung Cancer (SCLC).
SIADH
ectopic ADH secretion by the tumor causes clinically significant hyponatremia in 5-10% of SCLC patients
This class of agent for endocrine therapy for hormone receptor positive breast cancer is ineffective in women with functioning ovaries.
Aromatase Inhibitors (e.g., Anastrozole)
AI are preferred, but SERMs (tamoxifen & raloxifene) are approved for women without functioning ovaries if c/i to AI.
Of the NRTs (patch, gum, lozenge, inhaler, spray), which provides the fastest nicotine delivery?
Nasal Spray
A drug known to cause drug-induced lupus and pleural/parenchymal lung disease.
Hydralazine or Procainamide
irregular shaped cysts and nodules (cavitations) in the upper lobes of a smoker; spares bases
Pulmonary Langerhans Cell Histiocytosis (PLCH)
myeloid neoplastic disorder with inflammatory features, driven by somatic mutations in the MAPK pathway (particularly BRAF V600E and other RAS-RAF-MEK cascade mutations present in over 85% of cases)
The screening criteria for Low Dose CT (age range) per USPSTF
Ages 50-80
Breast MRI screening is added to mammography if lifetime risk exceeds this percentage.
>20-25%
This is how you should characterize the safety of using varenicline and CNRT together?
Safe and often more effective
HRCT pattern showing subpleural sparing, ground-glass opacities, and absence of honeycombing.
Nonspecific Interstitial Pneumonia (NSIP)
Cystic lung disease associated with renal chromophobe tumors and fibrofolliculomas.
Birt-Hogg-Dubé Syndrome
First-line treatment for EGFR-mutated metastatic NSCLC.
Osimertinib (3rd gen TKI), or osimertinib plus platinum-pemetrexed chemotherapy, or amivantamab (anti-EGFR & anti-MET) plus lazertinib (3rd gen EGFR TKI), all of which are preferred options
Common side effect of Tamoxifen that is not seen with Aromatase Inhibitors.
VTE or Endometrial Cancer
Recommended time to start Varenicline prior to the "Quit Date".
1 week prior
DPLD caused by amiodarone toxicity often shows this density on non-contrast CT
High attenuation (bright) consolidation (due to iodine content)
Serum marker elevated in Lymphangioleiomyomatosis (LAM).
VEGF-D
"Popcorn" calcification pattern in a solitary pulmonary nodule suggests this benign diagnosis.
Hamartoma
when popcorn calcification is clearly evident on chest imaging, no additional evaluation is necessary
Medication used for chemoprevention in postmenopausal women with high breast cancer risk and osteoporosis.
Raloxifene
This SERM is used for dyspareunia (GSM) but can worsen hot flashes.
Ospemifene
nearly full estrogen agonist activity on vaginal epithelium while antiestrogenic effects in breast tissue potentially protective against BrCA.