Can I Help you, MS?
You're getting on my nerves.
De-myalen-nation! Must say in a Jamaican accent.
GBS - Goofy Bear Society?
Seafaring adventures!
100
Used for treatment of acute MS relapses - promote recovery from acute demyelinating event.
What are glucocorticoids? Would you use these in treatment of GBS? (5 bonus points)
100
Key diagnostic tool to confirm demyelination.
What is an MRI? In MS, brain MRI is abnormal 95-99% of the time, although several other disease states are associated with a similar pattern.
100
The most common of the demyelinating diseases.
What is Multiple Sclerosis (MS)? Name the most prevalent subtype (70-85% of cases) for 10 bonus points.
100
Sleeves of lipoprotein plasma membranes of these cells wrap around axons in the PNS.
What are Schwann cells?
100
This man authored the tale of the great white whale - narrated by a man named Ishmael.
Who is Herman Mehlville?
200
What are glucocorticoids? Would you use these in treatment of GBS? (5 bonus points)
What is plasmapheresis?
200
The principal viral demyelinating disease in humans.
What is Progressive Multifocal Leukoencephalopathy? Name the virus and the condition a patient would need to be in to contract it. (20 bonus points)
200
The most prevalent symptom at onset for patients with MS (34%).
What is sensory disturbance? Explain why a patient may experience sensory disturbance with a demyelinating disease like MS for 20 bonus points.
Most commonly noted are paresthesias, as well as a 'squeezing sensation around the limbs'. Additionally, a common manifestation is unilateral numbness that spreads bilaterally and upwards over time, indicating spinal cord involvement.
Lhermitte is useful to localize to the cervical spinal cord. Sensory disturbances from MS flares generally resolve but occasionally evolve into chronic neuropathic pain.
Fatigue is common as well.
200
Perivenular plaques give rise to the distinct appearance of these lesions. Hint: Named after a Scottish pathologist.
What are Dawson fingers? Typically, multiple areas of high signal intensity are present on T2-weighted imaging and have a round or ovoid appearance. Often located in the corpus callosum and periventricular, juxtacortical, deep white matter and subcortical white matter.
200
This waxy substance extracted from the head cavity of a specific whale species was a hot commodity of the seas as early as the 17th century.
What is spermaceti (sperm oil)?
300
One of two treatment options considered for GBS, this medication requires at least 1000 donors for production.
What is IVIG? IVIG is the pooling of plasma extracted and purified from at least 1000 donors. Undetermined mechanism of action in GBS patients, but one theory besides preventing autoantibody attack on myelin is that the high IgG concentration accelerates the destruction of IgG.
300
Inflammatory condition resulting from demyelination of the optic nerve; degrades vision in one or both eyes.
What is optic neuritis? The initial inflammatory event in 15-20% of patients with MS.
300
Acute idiopathic autoimmune demyelinating disease of the PNS characterized by acute flaccid ascending neuromuscular paralysis.
What is Guillain-Barre Syndrome?
300
The common findings in CSF for patients with GBS.
What are increased protein and normal to elevated leukocytes?
300
This man was the first to circumnavigate the globe by ship.
Who is Ferdinand Magellan?
400
Cytokines secreted by immune cells that inhibit viral replication.
What are interferons? While IFN-gamma worsens the disease, the potent regulatory function of IFN on the immune system and its anti-inflammatory properties appears to be beneficial for some MS patients. risk for liver function abnormalities, leukopenia, thyroid disease, and possibly depression
400
THE TREASURY PRINTS MORE BILLS IN THESE 2 DENOMINATIONS THAN ANY OTHER
What are the $1 and the $20?
400
Diagnosis of MS relies on p_____ r_______. Hint: Machine learning
What is pattern recognition? Let's say a patient developed optic neuritis, and several months later developed cerebellar ataxia. Recognizing the pattern of acute attack, remission, and secondary attack in a different location is essential to diagnosing MS. Subtract 10 if you get this wrong.
400
This many weeks after onset of weakness, abnormal findings in nerve conduction studies are most pronounced in patients with GBS.
What is 3-4 weeks?
400
The fastest fish in the ocean.
What is the sailfish?
500
Monoclonal antibody used in treatment of MS to bind to lymphocytes, monocytes, basophils, and eosinophils.
What is Natalizumab? Prevents lymphocyte binding to the vascular endothelium and reduces inflammation.
500
ON JULY 20, 1999 IT WAS 30 YEARS SINCE THIS MAN SAID, 'HOUSTON... THE EAGLE HAS LANDED'
Who is Neil Armstrong?
500
Characteristic demyelination and remyelination of affected axons in this disease result in an 'onion-bulb' deformity of axons on biopsy - the disease lasts >8 weeks unlike GBS and has often has >3 relapses during those eight weeks.
What is Chronic Inflammatory Demyelinating Polyneuropathy?
500
This cutaneous nerve provides sensation to the posterolateral aspect of the distal third of the leg and the lateral aspect of the foot, heel, and ankle - is commonly untouched specifically in GBS.
What is the sural nerve?
500
This easternmost country of Europe led great voyages during the Age of Discoveries in the 15th and 16th centuries.
What is Portugal?