Med Chem
Secondary amine groups are absorbed _____ and have ______ bioavailability
What is rapidly and high
Goal of therapy in treating depression is to increase these three monoamine neurotransmitters
What is Dopamine, Serotonin, Norepinephrine
The gold standard scale used to determine level of depression in patients
What is the HAM-D Scale
The most sedating SSRI with the shortest half-life
What is Paroxetine
What is the preferred agent in patients who are pregnant
What is Sertraline
Paroxetine and Sertraline are constrained analogues of which other drug
What is fluoxetine
The name for the ability of neurons to "remodel" and adapt to changing demands
What is Synaptic Plasticity
A non-pharmacologic treatment option for depression
Light Box Therapy, Psychotherapy, Physical Activity
An SNRI that has a high risk for causing hepatotoxicity
What is Duloxetine
Class of medications that should be avoided in patients with a significant cardiac history due to their cardiovascular side effects (arrythmias)
What are TCA's
Non Hydrazines like tranylcypromine are what kind of inhibitors of MAO
What is irreversible, non-selective
This SSRI medication has the longest half-life
What is Fluoxetine
Black Box Warning for Antidepressants
What is increased risk of suicidal thinking/behavior in children, adolescents and young adults (< 24 years old)
A medication contraindicated in seizure disorders and eating disorders (bulimia)
What is Bupropion
Time frame in which we see maximum therapeutic effect of an antidepressant
What is 4-6 weeks
SNRIs have the ability to block which transporters
What is SERT and NET
An antidepressant that works though antagonism of the 5HT2 receptor
What is Trazodone OR Nefazodone
Return of symptoms after 6 months of treatment is considered
What is Remission
A medication that is sedating at lower doses, activating at higher doses and has a side effect for significant weight gain
What is Mirtazapine
A 60- hour infusion that is used to treat Post-partum Depression
What is brexanolone
Tertiary amine TCA's have what kind of bioavailability
What is low
The main adverse effect of MAOI's that prevents them from being first-line agents
What is Hypertensive Crisis
An alternative/complementary therapy for treatment of depression
What is St. Johns Wort OR SAMe OR Omega-3 Fatty Acids OR 5-HTP
If a patient has neuropathic pain in addition to depression, which medication class may be the most beneficial
What are SNRIs
First line augmentation strategies for patients who have failed antidepressant monotherapy therapy
What is Aripiprazole OR Risperidone OR Quetiapine