Who Are These People?
What is the most common contributing factor to Acute Renal Failure?
Septic Shock
Ref: Uchino, Acute Renal Failure in Critically Ill Patients. A Multinational, Multicenter Study.
Who authored the publication that indicated early renal replacement therapy reduced 90-day mortality in critically ill patients with AKI by more than 30
%?
Zarbock, The ELAIN Randomized Control Trial
In Thompson-Bastin et. al.'s publication on Phosphate-Containing Solutions, how was Hypophosphatemia defined?
Serum Phosphate <2.5mg/dL
Thompson-Bastin: Association of Phosphate Containing Solutions with Incident Hypophosphatemia in Critically Ill Patients Requiring CRRT
Who authored the publication that showed fluid overload was independently associated with mortality in patients with AKI?
Bouchard, Fluid accumulation, survival and recovery of kidney function in critically ill patients with AKI. (Also known as PICARD study).
Do we have a publication to support the objection of the use of Phoxilium related to hypoglycemia?
Yes
Crowley: Serum Glucose and Phosphorus Concentrations during CRRT Using Replacement Solutions with or without Phosphorus
In what percent of ICU patients does ARF present?
5-6%
Ref: Uchino, Acute Renal Failure in Critically Ill Patients. A Multinational, Multicenter Study.
***DAILY DOUBLE***
Part 1: What systematic review compared IRRT and CRRT associated dialysis dependence?
Part 2: What were the findings in relation to CRRT?
1: Schneider et al., Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury.
2: Among AKI survivors, initial treatment with IRRT might be associated with higher rates of dialysis dependance that CRRT.
***DAILY DOUBLE***
Part 1: What size molecule is Phosphorous considered to be?
Part 2: Phosphorus is removed during what CRRT modality(ies)?
Part 1: Small
Part 2: Phosphate is readily removed through diffusion and convection with CRRT (CVVH, CVVHD, and CVVHDF)
Thompson-Bastin: Association of Phosphate Containing Solutions with Incident Hypophosphatemia in Critically Ill Patients Requiring CRRT
How did Bouchard, et.al. define fluid overload?
Fluid overload was defined as more than a 10% increase in body weight relative to baseline.
This publication is "all about the Bemjamins" related to cost analysis of CRRT solutions
Shaw: Preparation Times and Costs for Various Solutions Used for CRRT
In critically ill patients with AKI, including those with multi-factorial AKI, what is the predicted mortality?
In critically ill patients with AKI, mortality rates range from 50-70% and have usually been attributed to multiple complications related to AKI, such as infections, bleeding, and fluid overload.
Ref: Bouchard, Fluid accumulation, survival and recovery of kidney function in critically ill patients with AKI.
This randomized control trial indicated longer postponement of RRT initiation was associated with a significant increase in mortality.
Gaudry, AKIKI II Randomized Controlled Trial
The administration of ___________-based replacement fluids during CRRT is an effective way to avoid exacerbation of hyperlactatemia and restore acid-base homeostasis.
Bicarbonate
Tan: The Acid-Base Effects of Continuous Hemofiltration with Lactate or Bicarbonate Buffered Replacement Fluids
In comparing IRRT vs. CRRT in fluid accumulation, what were Bouchard, et.al. findings?
Patients on CRRT were more likely to reduce the percentage of fluid accumulation compared with patients treated with IRRT.
This publication focuses on the cost-effectiveness of IRRT vs CRRT as initial therapy for AKI in the ICU
Ethgen: Economics of Dialysis Dependence Following Renal Replacement Therapy for Critically Ill AKI Patients
This analysis concluded that CRRT is cost-effective compared with IRRT when rates of subsequent dialysis dependence for each modality are considered