Build-A-Panel
This gold standard assay is required for every antibody used in DPA.
What is Immunohistochemistry?
This is the year that the first automated commercial platform for spatial biology, GeoMx, was launched.
What is 2019?
You can't get this from RNA, and there are 137 of them.
What are post-translational modifications (PTMs)?
This analytical tool measures the mass-to-charge ratio (m/z) of peptides in a sample.
What is mass spectrometry?
Antibodies, also known as immunoglobulins (Ig), are large, Y-shaped glycoproteins produced as primary immune defense by this type of cell.
What is a B cell?
This type of conjugation connects the oligo to antibodies in IPA and NPA, but not the core.
What is Cys conjugation?
Two of these key components inside the GeoMx instrument are used to focus UV light onto the tissue sample to achieve nondestructive "microdissection" by light.
What are the digital mirror devices (DMDs)?
These five housekeepers in the Core serve as positive controls.
What is GAPDH, Histone H3, RPS6, TOMM20, and Calreticulin?
This year is when Spatial Proteomics earned the distinction of being named Nature's Method of the Year.
What is 2024?
NanoString was spun out of The Institute for Systems Biology and founded as a separate company in 2003 by Krassen Dimitrov, Amber Ratcliffe, and this person who likes to ski.
Who is Dwayne Dunaway?
You can say this is our protein "plex" or how many antibodies are in DPA.
What is 1,232?
Regions-of-interests can be further segmented into these compartments, like tumor and tumor microenvironment.
What are Areas-of-Illumination?
NPA added three new functional annotations to IPA. Along with "elongation factors" and "translation factors", this functional annotation added 21 new targets including Ionotropic Glutamate receptor 2, Ryanodine Receptor, and VDAC1/Porin.
What is "Ion Channels"?
Illumina acquired SomaLogic in June 2025 for $350M, and can measure 9,500 protein in plasma or serum with this type of affinity reagent.
What are aptamers?
DAILY DOUBLE!
Comprehensive blood disease atlas, expanded single cell resource to 154 cell types, and AI protein interaction resource based on 3D structure of 23K pairings, are some of the new features added to this recently launched version of this website.
For DPA, there are 768 of them.
What are Pro Code Indices?
In January 2020, two landmark GeoMx studies were published back-to-back in the journal Nature describing this B-cell enriched structure in tumor tissues.
What is Tertiary Lymphoid Structures?
DPA targets 143 of these types of proteins, including ATM, EGFR, and mTOR.
What are kinases?
Given a HeLa cell is 3000 um^3, about how many proteins are in one HeLa cell?
What is 10^10?
This is the single most abundant protein in the human body, and it's not hemoglobin, myosin, and keratin.
What is collagen?
This is the "better" amount of ug of antibody to build our high plex protein panels.
What is 100 ug?
GeoMx can target histological tissue structures like glomeruli in kidney and Islet of Langerhans in pancreas, which is this average size in diameter.
What is 200 microns?
DAILY DOUBLE!
This is the top Pathway Annotation in DPA with 355 targets, after "Neurogenesis" at #2 and "Cytokine Signaling" at #3.
This is the largest spatial proteomics assay on the market.
What is Discovery Proteome Atlas?
In 1665, this famous Scientist collected his microscope drawings in Micrographia, including a louse, a flea, and cork...oh and he coined the term "cell".
Who is Robert Hooke?