Clinical Manifestations
Profound motor function loss, sensory modality is intact.
What is preserved sensation?
Loss of input from innervation causes muscles to shrink in this disease.
What is Denervation Atrophy?
This test can be performed to identify denervation patterns but cannot confirm the disease.
One of the first approved medications for this class disease, it works by reducing central nervous system glutamate levels to slow neuronal damage
What is Riluzole
Hypothesis / theory that suggests the origins of the disease stem from the peripheral nerves neuromuscular junction. Which then, nerve cell death progresses leading to systemic loss of neurons motor unit thus decrease muscle use and atrophy.
Genetic form of this disease involves mutation in an enzyme that neutralises free radicals.
What is superoxide dismutase (SOD1)?
what is apoptosis?
Test done to measure the presence of these antibodies to rule out Myasthenia Gravis (not disease of game)
what are Acetylcholine receptor antibodies (AchR Ab)?
FDA approved antioxidant medication used to reduce oxidative stress in effect slowing down the decline of physical function seen in this disease
What is edravone
Original name for this disease, stemming from the New York Yankees baseball player who was diagnosed with the disease in 1939.
What is Lou Gehrig's Disease
Weakness in muscles controlling swallowing causes major difficulty eating a meal.
What is dysphagia?
These highly reactive species cause neural damage as a result of losing enzyme function.
What are ROS (Reactive Oxygen Species)?
A test to determine Muscle atrophy and twitching in these neurons
What is EMG of lower motor neurons?
This type of clinical trial design, used in studying this particular disease. It includes testing of multiple drugs administered at the same time against a shared placebo group
“ platform trail “
Most common form of the disease. Accounting for about 90% of all cases. being known to occur randomly
This disease is known for causing painful involuntary muscle squeezing and contractions.
What are muscle cramps?
Too much of this excitatory neurotransmitter causes neurons to die and contributes to the loss of innervation.
What is Glutamate?
Trouble speaking and swallowing indicates damage to this region.
Also accept, what is the medulla?
This is a surgical procedure that’s creates an opening in the windpipe mechanical ventilation in late-stages of in the later stages of the disease
what is a tracheostomy
Specialized medical care that focuses on improving quality of life for patients will serious illnesses with poor outcomes.
Palliative care
These two functions are spared in this disease.
What are sensation and bowel/bladder function?
Disruption of this process causes proteins and organelles to accumulate within the axon.
What is Axon transport?
This test is done to measure muscle activity and if it is innervated.
what is EMG (Electromyography)?
the main focus of treatment seen in this disease that aims to symptomatic ally curbs the physical ailments this disease causes.
What is physical therapy
A famous physicist who lived with a slow-progressing form of the disease for over 50years, defying there original life expectancy prognoses.
What is “ Stephen Hawking “