Vocab
A change to gene activity without changing the DNA itself; influenced by environment
What is epigenetics?
Is silenced or reduced by DNA methylation to regulate gene expression
What is transcription?
Some genes activate immune responses while others suppress it; shows balance
What is normal immune regulation?
A condition in which the immune system attacks the body; can be caused by an overactive immune system
What is autoimmune disease?
Act as epigenetic markers for methylation
What are CpG sites?
The states of disease that can change DNA methylation patterns
What are active and remission?
Cells control which genes are turned on or off; not all genes are active at once
What is gene expression?
Are added to molecules to block transcription and silence genes
What are methyl groups?
Most common effects of lupus
What are inflammation and damage to organs?
Acts like a dimmer switch for genes; methyl groups attach to DNA to block transcription factors
What is DNA methylation?
What are the small molecules that increase the protein EZH2?
What are microRNAs?
The percentage increase in antinuclear antibodies for 12-19 year olds between 1988 and 2012
What is 300%?
A condition in which the immune system mistakenly attacks healthy tissues, causing widespread inflammation and damage to organs
What is lupus?
A protein that causes methylation specifically in lupus
What is EZH2?
Can cause flare-ups when they are overactive
What are immune cells?